Thanks, reading the paper now. Issues that occur to me so far:
It's mainly for hospitalized patients - how many of these would have died whatever happened? It's hard to tell from the paper directly, since it cites other estimates from around ten years before, and I haven't been able to read them yet.
How many people's lives have been saved or improved by "big pharma"? Same question for illegal drugs and Aurora-style massacres. Yes, it's silly question, but your equivalence between "big pharma" and illegal drugs is why we're having this little debate.
The number of deaths due to adverse effects forms less than half of the deaths from iatrogenic causes - is the problem really "Big Medical system as a whole"? I know a lot of people are happy to posit a conspiracy by the drug companies but are reluctant to blame medical professionals for whatever reason. Recognition that human errors occur, and learning from those errors, is to my mind more important than belittling the work that everyone involved in humand and animal health is doing.
Yup, I'm in favour of pharmaceutical drugs. I've had cause to take several of them in the past, mostly for mental issues (OCD, anxiety, etc.), but also migraines. In all cases except one (a doctor nearing retirement and seemingly a bit out of touch and too eager to hand out the happy pills), the medical professionals have been very reluctant to prescribe unnecessarily, recommending therapies such as CBT before drugs, waiting to see how those therapies progressed and giving me assistance in eventually terminating treatment when its work was done (ie tapering programs for anti-depressants). YMMV, since I'm a happy customer of the NHS and I suspect you don't have a similar system.