I was a graduate student in Ann Arbor at the beginning of the 90s. At the time, the Borders brothers still owned Borders, and there were just two Borders stores: one in (I think) Plainfield (a Detroit suburb), and the original store on State Street. I loved that store like I've never loved a bookstore. The best thing about it was the staff that worked there. To get a job there, you had to pass a written test; and if you showed expertise in a particular subject area, you got to take some responsibility for ordering and stocking that subject area. The result was that if you walked in looking for a book on numerical thermodynamics, or differences in translations of The Inferno, you had a pretty good chance of being able to ask questions of someone who knew about the topic and had ordered the books and could provide you with useful info. Under no circumstances at all were you being helped by a high school kid who didn't know much of anything about the merchandise.
Then the brand got sold (to Waldenbooks/K-Mart, I believe), the State Street store moved into larger quarters (the old Jacobsen's store), they exploded coast-to-coast, and I found myself wandering into Borders in other cities that were certainly big, but didn't have the single biggest thing I liked about Borders: an exceptionally competent staff. Their newer owners had decided to compete purely on price and selection; it was inevitable that an internet vendor was eventually going to be able to beat them on those.
Which leaves me missing what I liked about them in the first place, something no internet vendor (even Amazon) has really replaced.