Realistically, blocking the ability of gamers to sell their used games isn't likely to be that much of a concern. PC gamers have already shown they're willing to accept that when coupled with reasonably sensible pricing schemes (eg. Practically any PC game download service, such as Steam).
The real problem for a company trying to implement something like this is going to be with the stores. Historically, stores such as Gamestop have only minimal margins on the sales of actual gaming consoles. (The Wii is a rare and notable exception there, and the Wii U is unlikely to be different on that score.) It's the same kind of razor & blades business model that Microsoft and Sony use selling them the consoles in the first place (though not as extreme, since Microsoft and Sony usually lose money on each console sold.) This is why many stores try to up-sell you to a bundle when you're buying a console, since they make so much more on the margin of those games (even the ones that they seemingly discount dramatically for the purpose of the bundle).
If you eliminate the possibility of these stores selling used games on a console, then you're leaving them only with new games (average margins) and consoles (minimal margins). What do you think will be the result of that? Most likely, they'll shift shelf space to something with better margins, if not eliminate the product line from their stores entirely. After all, when a games store sells you a console, they're hoping to continue to make money from you from game sales in the future. If you can't buy used games from them, then your value as a customer to them has just decreased dramatically.
