LIQUi|> serves as a comprehensive software architecture and toolkit specifically designed for quantum computing applications. It features a programming language alongside optimization and scheduling algorithms, as well as quantum simulation capabilities. This tool enables the conversion of high-level quantum algorithms into the low-level machine instructions needed for quantum devices. The development of LIQUi|> is being spearheaded by the Quantum Architectures and Computation Group (QuArC) at Microsoft Research. QuArC has crafted this extensive software platform to facilitate the exploration and comprehension of various quantum protocols, algorithms, error correction methods, and devices. Additionally, LIQUi|> provides functionalities for simulating Hamiltonians, quantum circuits, stabilizer circuits, and noise models, while also accommodating client, service, and cloud-based operations. This comprehensive toolkit is an essential resource for researchers and developers venturing into the realm of quantum computing.