Flywheel provides comprehensive data management solutions to researchers looking to improve productivity and collaboration in imaging research and clinical trials, multi-center studies, and machine learning. Flywheel provides end-to-end solutions that streamline data ingestion and curate it to common standards. We also automate processing and machine-learning pipelines. Our platform allows for secure collaboration in the life sciences, clinical, academic, as well as AI, industries. Cross-platform data and algorithm integration, secure and compliant data discovery among a global network, and cloud-scalable and on-premise computational workflows to support research and clinical applications. Flywheel is a data curation platform that supports multi-modality research. It can manage a wide range of data types, including digital pathology, imaging files, clinical EMR data and omics, as well as instruments.