Simulations Plus Reviews

You can share clinical and pre-clinical knowledge easily across your organization using a single platform that integrates all the tools you need. Phoenix WinNonlin is the preferred choice for non-compartmental analysis, toxicokinetic modeling, pharmacokinetic, and pharmacokinetic (PK/PD), modeling by more than 6,000 researchers from biopharmaceutical companies and academic institutions. It also includes 11 global regulatory agencies including the US FDA (EMA), PMDA, and more. The Phoenix Platform features population PK/PD modeling using Phoenix NLME and Level 1 correlation via the Phoenix IIVC Toolkit. Validation Suites allow for quick and easy software validation in less than 30 minutes.

BioNeMo, an AI-powered cloud service for drug discovery and framework, is built on NVIDIA NeMo Megatron. It is used to train and deploy large biomolecular Transformer AI models at supercomputing scale. The service provides pre-trained large language models (LLMs), native support for common file types for proteins, DNA, and chemistry, as well as data loaders for SMILES molecular structures and FASTA amino acid and nucleotide sequencings. You can also download the BioNeMo framework to run on your own infrastructure. ESM-1, which is based on Meta AI’s state-of the-art ESM-1b and ProtT5 respectively, are transformer-based protein-language models that can be used for learning embeddings for tasks such as property prediction and protein structure. BioNeMo will offer OpenFold, a deep-learning model for 3D structure prediction and novel protein sequences.