Best Endpoint Detection and Response (EDR) Software for Microsoft 365

Find and compare the best Endpoint Detection and Response (EDR) software for Microsoft 365 in 2026

Use the comparison tool below to compare the top Endpoint Detection and Response (EDR) software for Microsoft 365 on the market. You can filter results by user reviews, pricing, features, platform, region, support options, integrations, and more.

  • 1
    Safetica Reviews
    Top Pick
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    Safetica Intelligent Data Security protects sensitive enterprise data wherever your team uses it. Safetica is a global software company that provides Data Loss Prevention and Insider Risk Management solutions to organizations. ✔️ Know what to protect: Accurately pinpoint personally identifiable information, intellectual property, financial data, and more, wherever it is utilized across the enterprise, cloud, and endpoint devices. ✔️ Prevent threats: Identify and address risky activities through automatic detection of unusual file access, email interactions, and web activity. Receive the alerts necessary to proactively identify risks and prevent data breaches. ✔️ Secure your data: Block unauthorized exposure of sensitive personal data, trade secrets, and intellectual property. ✔️ Work smarter: Assist teams with real-time data handling cues as they access and share sensitive information.
  • 2
    Iru Reviews

    Iru

    Iru (formerly Kandji)

    1,488 Ratings
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    Iru AI reimagines enterprise security and IT management with a unified, AI-driven platform that eliminates tool fragmentation and operational overhead. At its core is the Iru Context Model, a dynamic intelligence layer that connects identity, endpoint, and compliance management into one cohesive ecosystem. The platform offers passwordless authentication, device-bound access policies, and real-time vulnerability detection—creating a trust fabric that safeguards every user and device. Iru’s endpoint suite integrates management, detection, and response capabilities across Apple, Windows, and Android environments for holistic protection. Its Compliance Automation engine continuously maps and updates controls, ensuring organizations remain audit-ready while accelerating deal cycles. By merging automation with contextual intelligence, Iru empowers IT and security teams to make faster, smarter decisions. Companies gain a consolidated view of their infrastructure, reducing zero-day exploit risks and boosting productivity across teams. With a 4.75/5 G2 rating and adoption by thousands of high-growth enterprises, Iru delivers a future-ready foundation for secure, intelligent business operations.
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    Syncro Reviews
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    Syncro

    Syncro

    $129 per user per month
    25 Ratings
    Syncro is the integrated business platform for running a profitable MSP. Enjoy PSA, RMM, and remote access in one affordable package. PLUS! Integrations to 50+ MSP and business tools you also love and use amp your efficiency even more. Syncro pricing is refreshingly simple—one flat fee for all PSA, RMM, and remote access features. Unlimited endpoints, no contracts, no minimums.
  • 4
    ConnectWise Cybersecurity Management Reviews
    ConnectWise Cybersecurity Management (formerly ConnectWise Fortify) software and support solutions help MSPs protect their clients’ critical business assets. From 24/7 threat detection monitoring, incident response, and security risk assessment tools, ConnectWise Cybersecurity Management solutions remove the complexity associated with building an MSP-powered cybersecurity stack and lower the costs of 24/7 monitoring support staff.
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    Xenex Reviews
    XeneX offers a comprehensive solution that not only features highly adaptable security tools but also ensures round-the-clock access to elite security professionals for ultimate reassurance. The SOC Visibility Triad, as defined by Gartner, presents a multifaceted method for detecting and responding to network threats. XeneX enhances this concept by introducing its cutting-edge SOC-as-a-Service, which progresses from merely presenting data and dashboards to delivering profound clarity and insightful correlations. This service incorporates everything necessary straight out of the box, including the state-of-the-art proprietary XDR+ engine, making it a complete Cloud Security Operations Center (SOC) solution supported by a top-tier global security team that guarantees thorough peace of mind. By employing advanced cross-correlation (XDR) technologies, XeneX elevates the standards of threat detection and response significantly. For further information, continue reading below to discover more about the innovative features and advantages XeneX has to offer.
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    WithSecure Elements XDR Reviews
    WithSecure's modular Elements Cloud cyber security platform seamlessly integrates Extended Detection and Response (XDR), Exposure Management (XM) and Co-Security Services into a single unified solution. - WithSecure Elements XDR includes Elements Endpoint Security (your EPP+EDR), Identity Security for Microsoft Entra ID, Collaboration Protection for Microsoft 365, and Cloud Security for Azure as modules. You can flexibly choose which capabilities to include in your Elements XDR solution. - WithSecure Elements Exposure Management (XM) is a continuous and proactive solution that predicts and prevents breaches against your company’s assets and business operations. Elements XM provides visibility into your attack surface and enables the efficient remediation of its highest-impact exposures through a unified view, thanks to our exposure scoring and AI-enabled recommendations. Get one solution for 360° digital exposure management and visibility across your external attack surface and internal security posture, to proactively prevent cyber-attacks. Through our flexible Elements modules made of cutting-edge software and high-quality services, customers can find the optimal solution for their needs. Together, the modules offer end-to-end business and cloud coverage. In today's unpredictable, ever-changing business environment, our all-in-one security platform helps you build and maintain a resilient business. We believe in the European Way of cyber security and we do this together with our partners as the Elements Cloud is really geared to enable WithSecure’s partners to offer robust security products and managed security services to mid-sized and other resource constrained companies.
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    Defense.com Reviews

    Defense.com

    Defense.com

    $30 per node per month
    Take charge of your cyber threats effectively by utilizing Defense.com to identify, prioritize, and monitor all your security risks in one streamlined platform. Simplify your approach to cyber threat management with integrated features for detection, protection, remediation, and compliance, all conveniently consolidated. By leveraging automatically prioritized and tracked threats, you can make informed security decisions that enhance your overall defense. Improve your security posture by adhering to proven remediation strategies tailored for each identified threat. When challenges arise, benefit from the expertise of seasoned cyber and compliance consultants who are available to provide guidance. Harness user-friendly tools that seamlessly integrate with your current security investments to strengthen your cyber defenses. Experience real-time insights from penetration tests, vulnerability assessments, threat intelligence, and more, all displayed on a central dashboard that highlights your specific risks and their severity levels. Each threat is accompanied by actionable remediation advice, facilitating effective security enhancements. Additionally, your unique attack surface is mapped to powerful threat intelligence feeds, ensuring that you are always one step ahead in the ever-evolving landscape of cyber security. This comprehensive approach enables you to not only address current threats but also anticipate future challenges in your security strategy.
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    ESET PROTECT Elite Reviews

    ESET PROTECT Elite

    ESET

    $275 one-time payment
    ESET PROTECT Elite serves as a top-tier cybersecurity platform designed for enterprises, seamlessly combining extensive detection and response capabilities with a robust multilayered defense system. Utilizing cutting-edge techniques like adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis, it effectively combats zero-day vulnerabilities and ransomware threats. The solution delivers modern endpoint protection for both computers and mobile devices, along with server security that ensures real-time data safety and mobile threat defense. Additionally, it incorporates full disk encryption, which aids organizations in meeting data protection compliance requirements. ESET PROTECT Elite also boasts powerful email security features that encompass anti-phishing, anti-malware, and anti-spam measures, while providing protection for cloud applications such as Microsoft 365 and Google Workspace. Its vulnerability management and patch capabilities automate the identification and remediation of security flaws across all endpoints, fostering a proactive approach to cybersecurity. Overall, ESET PROTECT Elite is a comprehensive solution that addresses the evolving challenges of modern cybersecurity threats.
  • 9
    Microsoft Defender for Business Reviews
    Microsoft Defender for Business offers advanced, AI-powered cybersecurity protection built specifically for small and medium-sized organizations. It consolidates multiple security capabilities into a single solution, reducing costs while improving protection. The platform safeguards devices against ransomware, malware, phishing, and emerging threats across major operating systems. Built-in vulnerability management helps businesses discover and fix misconfigurations before they can be exploited. AI-powered endpoint detection and response works continuously to detect attacks and automatically stop them. Automated investigation and remediation reduce the need for manual security intervention. Defender for Business supports both office-based and remote employees with consistent device protection. Wizard-based setup and out-of-the-box security policies simplify deployment and management. Monthly security reports provide visibility into threats and overall security posture. Microsoft Defender for Business delivers enterprise-level protection without enterprise-level complexity.
  • 10
    Trava Reviews
    Your cybersecurity requirements are distinct, necessitating tailored solutions. We guide you through every phase of your assessment, compliance, and insurance experience, ensuring you never feel lost. While your goal might be to secure compliance with industry standards like SOC2 or ISO27001, the journey is broader and more dynamic. At Trava, we equip you with advanced tools to help close the gap between your current position and your goals, empowering you to evaluate risks, address the most critical vulnerabilities, and mitigate risks through insurance options. Our user-friendly platform enhances your understanding of security and risk factors related to potential clients, enabling insurance carriers to make more educated policy decisions, often resulting in more competitive quotes. Achieving compliance is a vital element of an all-encompassing cybersecurity strategy. At Trava, we are dedicated to supporting you throughout your compliance journey, helping you expand your service portfolio, boost your revenue, and establish yourself as a reliable strategic ally for your clients. In addition, our commitment to innovation ensures that you stay ahead in an ever-evolving threat landscape.
  • 11
    Cybraics Reviews
    Eliminate the need to constantly monitor alerts and proactively avert incidents before they occur with the premier XDR platform that transforms how threats are detected, logs are managed, and responses are coordinated. Bridge existing gaps and empower your team with our top-tier, integrated XDR solution that not only ensures compliance but also streamlines security operations. Cybraics nLighten™ stands out as more than just a standard security tool; it emerged from advanced AI and machine learning initiatives conducted alongside the U.S. Department of Defense, serving as a key resource for extracting actionable insights from the dispersed and isolated data, logs, and alerts generated by various security tools within your infrastructure. With Cybraics, achieving robust threat detection is accessible and doesn’t have to strain your budget. Equipped with Adaptive Analytic Detection (AAD) and Persistent Behavior Tracing (PBT), this platform enhances the effectiveness of your security team by automating 96% of actionable case creation while significantly cutting false positives by 95%. Consequently, the time required for detection and response is dramatically reduced from months to mere minutes, allowing your organization to respond swiftly to potential threats. This innovative approach not only strengthens your security posture but also optimizes resource allocation across your team.
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    Zip Security Reviews
    Running a comprehensive security program with Zip requires no specialized knowledge, allowing you to streamline processes with one-click workflows for tasks such as account recovery and deploying CrowdStrike. We equip you with all the necessary tools to take immediate action, ensuring you never fall short of compliance standards. Keep an eye on your system's devices, identities, and third-party tools from a holistic perspective, allowing you to adjust each metric as necessary. Our platform seamlessly integrates top-tier security tools like CrowdStrike, Jamf, and Intune, creating a scalable enterprise security framework that is managed through a unified interface. You can establish uniform security policies across both Windows and macOS devices without the complications of platform-specific setups. Zip serves as your comprehensive partner for procuring, deploying, configuring, and overseeing your entire enterprise security strategy. We take charge of all software acquisitions required to satisfy your customers' expectations, insurance requirements, and compliance obligations, enabling you to focus on what truly matters—growing your business. With Zip, you can experience unparalleled peace of mind knowing your security program is in expert hands.
  • 13
    Obsidian Security Reviews
    Safeguard your SaaS applications from breaches, threats, and data leaks seamlessly. In just a few minutes, you can secure essential SaaS platforms like Workday, Salesforce, Office 365, G Suite, GitHub, Zoom, and more, using data-driven insights, vigilant monitoring, and effective remediation strategies. As businesses increasingly transition their critical operations to SaaS, security teams often struggle with a lack of cohesive visibility necessary for swift threat detection and response. They face challenges in addressing fundamental inquiries: Who has access to these applications? Who holds privileged user status? Which accounts have been compromised? Who is sharing files with external parties? Are the applications set up in accordance with industry best practices? It is crucial to enhance SaaS security measures. Obsidian provides a streamlined yet robust security solution designed specifically for SaaS applications, focusing on unified visibility, ongoing monitoring, and advanced security analytics. By utilizing Obsidian, security teams can effectively safeguard against breaches, identify potential threats, and take prompt actions in response to incidents within their SaaS environments, ensuring a comprehensive approach to security management.
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