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Average Ratings 0 Ratings

Total
ease
features
design
support

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Write a Review

Description

Aurora utilizes principles of quantum mechanics and thermodynamics alongside a sophisticated continuous water model to assess the solvation effects on ligand binding affinities. This methodology is significantly different from the traditional scoring functions typically employed for predicting binding affinities. By integrating entropy and aqueous electrostatic contributions directly into the computations, Aurora's algorithms yield far more precise and reliable binding free energy values. The interaction between a ligand and a protein is fundamentally defined by the binding free energy value. This free energy (F) serves as a thermodynamic measure that correlates directly with the experimentally determined inhibition constant (IC50), influenced by factors such as electrostatic interactions, quantum effects, aqueous solvation forces, and the statistical characteristics of the molecules involved. Non-additivity in F arises primarily from two key components: the electrostatic and solvation energy, and the entropy, which together contribute to the complexity of ligand-protein interactions. Understanding these contributions is essential for the accurate prediction of binding affinities in drug design and molecular biology.

Description

Spacemacs is a community-centric distribution of Emacs that revolutionizes the editing experience by integrating both Emacs and Vim's strengths. This innovative editor emphasizes ergonomic design, mnemonic organization, and consistency throughout its interface. Key bindings are thoughtfully categorized with mnemonic prefixes such as b for buffer, p for project, s for search, and h for help, making navigation intuitive. Users benefit from a unique real-time display that highlights available key bindings, enhancing usability. The platform also features a streamlined query system to effortlessly locate layers, packages, and more. With a standardized set of conventions, similar functionalities utilize the same key bindings across the board, promoting familiarity. Additionally, the community-driven configuration ensures that users have access to a curated selection of packages optimized by experienced users, while bugs are addressed promptly, fostering a reliable and efficient working environment. This makes Spacemacs not just an editor, but a vibrant community of users supporting one another in their coding journeys.

API Access

Has API

API Access

Has API

Screenshots View All

Screenshots View All

Integrations

C
C++
CSS
Erlang
F#
GitHub
Go
HTML
Haskell
Java
Lua
Markdown
PHP
Python
Racket
Ruby
SQL
Scala
Swift
TypeScript

Integrations

C
C++
CSS
Erlang
F#
GitHub
Go
HTML
Haskell
Java
Lua
Markdown
PHP
Python
Racket
Ruby
SQL
Scala
Swift
TypeScript

Pricing Details

No price information available.
Free Trial
Free Version

Pricing Details

No price information available.
Free Trial
Free Version

Deployment

Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook

Deployment

Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook

Customer Support

Business Hours
Live Rep (24/7)
Online Support

Customer Support

Business Hours
Live Rep (24/7)
Online Support

Types of Training

Training Docs
Webinars
Live Training (Online)
In Person

Types of Training

Training Docs
Webinars
Live Training (Online)
In Person

Vendor Details

Company Name

Aurora Fine Chemicals

Founded

1990

Country

United States

Website

aurorafinechemicals.com/drug-discovery-software.html

Vendor Details

Company Name

Spacemacs

Founded

2014

Website

www.spacemacs.org

Product Features

Product Features

Code Editors

API
Auto-Complete
Code Folding
Column Editing
Customizable Themes
Debugging
Formatting / Table Editing
Keyboard Shortcuts
Multi-Monitor Editing
Syntax Highlighting
WYSIWYG

Text Editors

API
Auto-Complete
Code Folding
Column Editing
Customizable Themes
Debugging
Formatting / Table Editing
Keyboard Shortcuts
Multi-Monitor Editing
Syntax Highlighting
WYSIWYG

Alternatives

Alternatives

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