NVIDIA NeMo Guardrails serves as an open-source toolkit aimed at improving the safety, security, and compliance of conversational applications powered by large language models. This toolkit empowers developers to establish, coordinate, and enforce various AI guardrails, thereby ensuring that interactions with generative AI remain precise, suitable, and relevant. Utilizing Colang, a dedicated language for crafting adaptable dialogue flows, it integrates effortlessly with renowned AI development frameworks such as LangChain and LlamaIndex. NeMo Guardrails provides a range of functionalities, including content safety measures, topic regulation, detection of personally identifiable information, enforcement of retrieval-augmented generation, and prevention of jailbreak scenarios. Furthermore, the newly launched NeMo Guardrails microservice streamlines rail orchestration, offering API-based interaction along with tools that facilitate improved management and maintenance of guardrails. This advancement signifies a critical step toward more responsible AI deployment in conversational contexts.