Skymel is an innovative cloud-native platform for AI orchestration that centers around its real-time Orchestrator Agent (OA) and the accompanying AI assistant, ARIA. The Orchestrator Agent facilitates the creation of both fully automated runtime agents and dynamic agents managed by developers, which can easily integrate with any device, cloud service, or neural network framework. Utilizing NeuroSplit’s advanced distributed-compute technology, it enhances inference efficiency by intelligently directing each request to the most suitable model and execution environment—whether that be on-device, in the cloud, or a hybrid setup—all while standardizing error handling and significantly lowering API costs by 40–95%, thus boosting overall performance. Built on the foundation of OA, Skymel ARIA provides a cohesive and synthesized response to any inquiry by coordinating real-time access to AI models like ChatGPT, Claude, and Gemini, effectively eliminating the need for cumbersome manual prompt chains and the hassle of managing multiple subscriptions. This seamless integration and orchestration of AI tools not only streamlines workflows but also empowers users with a more efficient and user-friendly experience.