The PICO MES platform empowers manufacturers to modernize and enhance their production processes by consolidating personnel, equipment, tools, and data into a singular cohesive system. This innovative solution provides digital work instructions that include detailed step-by-step guidance and engaging visual aids, along with real-time insights into throughput, yield, and operator efficiency, ensuring comprehensive traceability of every part's manufacturing history. It seamlessly integrates with various tools, including barcode scanners, torque tools, PLCs, vision systems, and ERP/PLM/QMS platforms, among others. Remarkably, PICO can be deployed in just minutes instead of months, connecting effortlessly with existing machinery and business applications without necessitating any major overhauls. This capability makes it suitable for manufacturers of all scales, from small enterprises moving away from paper-based processes to larger corporations optimizing operations across multiple sites. Moreover, its plug-and-play compatibility with over 200 devices and its modular design facilitate the enforcement of standardized work processes in environments characterized by high variability and low volume, allowing for automatic data collection and proactive responses to shop floor challenges as they arise. Ultimately, the PICO MES platform serves as a critical tool for manufacturers aiming to increase efficiency and streamline their operations.