A closed-loop universal multivariable optimizer is designed to enhance both the performance and quality of Model Predictive Control (MPC) systems. This optimizer utilizes data from Excel files sourced from Dynamic Matrix Control (DMC) by Aspen Tech, Robust Model Predictive Control Technology (RMPCT) from Honeywell, or Predict Pro from Emerson to develop and refine accurate models for various multivariable-controller variable (MV-CV) pairs. This innovative optimization technology eliminates the need for step tests typically required by Aspen Tech and Honeywell, operating entirely within the time domain while remaining user-friendly, compact, and efficient. Given that Model Predictive Controls (MPC) can encompass tens or even hundreds of dynamic models, the possibility of incorrect models is a significant concern. The presence of inaccurate dynamic models in MPCs leads to bias, which is identified as model prediction error, manifesting as discrepancies between predicted signals and actual measurements from sensors. COLUMBO serves as a powerful tool to enhance the accuracy of Model Predictive Control (MPC) models, effectively utilizing either open-loop or fully closed-loop data to ensure optimal performance. By addressing the potential for errors in dynamic models, COLUMBO aims to significantly improve overall control system effectiveness.