E-COMB, or EDI Compatible Medical Billing, serves as a web-based platform designed to create medical claims that adhere to the HIPAA transaction and code set standards mandated by the US Government in accordance with the guidelines established by the American National Standards Institute (ANSI). This solution facilitates the generation, submission, and reconciliation of claims directed towards insurance companies, guarantors, and patients, making it an essential resource for healthcare providers to optimize their revenue by significantly shortening the claims reimbursement process. Additionally, all pertinent information related to the operational context of a Doctor’s Office or Hospital is compiled as Master Data, which is often utilized for claims processing and tends to remain stable over time. This Master Data encompasses critical details regarding Procedures, Diagnoses, Doctors, Payers, and Billing Providers, among others, and is initially created during the setup phase, with the flexibility for updates as necessary. Consequently, E-COMB not only streamlines the billing procedure but also ensures that healthcare professionals have easy access to the most current and relevant information for their operations.