Atheris is a Python fuzzing engine guided by coverage, designed to test both Python code and native extensions developed for CPython. It is built on the foundation of libFuzzer, providing an effective method for identifying additional bugs when fuzzing native code. Atheris is compatible with Linux (both 32- and 64-bit) and Mac OS X, supporting Python versions ranging from 3.6 to 3.10. Featuring an integrated libFuzzer, it is well-suited for fuzzing Python applications, but when targeting native extensions, users may need to compile from source to ensure compatibility between the libFuzzer version in Atheris and their Clang installation. Since Atheris depends on libFuzzer, which is a component of Clang, users of Apple Clang will need to install a different version of LLVM, as the default does not include libFuzzer. The implementation of Atheris as a coverage-guided, mutation-based fuzzer (LibFuzzer) simplifies the setup process by eliminating the need for input grammar definition. However, this approach can complicate the generation of inputs for code that processes intricate data structures. Consequently, while Atheris offers ease of use in many scenarios, it may face challenges when dealing with more complex parsing requirements.