By "get out" I mean no military intervention, no foreign aid (except for emergencies like natural disasters), no weapons sales, and no immigration by mid-eastern nationals (except for very select cases).
1) Money, and weapons, always end up in the wrong hands.
Hamas is getting their money from Qatar. The US gave Qatar $11 billion. We might as well have given the money directly to Hamas. ISIS is using US military equipment. There are many more examples.
2) The US will be blamed, and hated, even more than it already is, by everybody in the world, especially Muslims.
Any military intervention will be called an invasion. The US will be accused of killing civilians to steal the oil of whatever mid-east nation we are "helping" this week. If we help tribe A, tribe B will hate us even more. Then tribe A will hate us as soon as we stop helping them. All casualties will be blamed on the US, even if most casualties are the result of Muslims killing other Muslims. And there is always that one-in-a-million soldier that does something completely out of line, and that is all the media will focus on.
3) The US can no longer afford the outrageous expense.
The US is drowning in debt. Our credit has been downgrading. Our economy is in the toilet. Yet we borrow more billions from China, to give to mid-eastern Muslim who hate us.
4) There are no "good guys"
Does it really matter if Syria, or Iraq, or whatever, is ran by insane Sunis, or equally insane Shites? Our friends today, are our enemies tomorrow. I believe both Saddam Hussan, and Osama bin Ladan where our buddies at one time. Between Assad and ISIS, who is the good guy? They all seem like murdering thugs, why pick sides?
5) Even if you win, you lose.
Over ten years, and I don't even know how many billions of dollars, or thousands of lives, or how much suffering, in Iraq. And now Iraq is being overrun by ISIS. Even before ISIS, it was non-stop terrorist attacks. If we stop ISIS than what? Peace for two weeks?
6) Other than buying oil, the US has no business there.
Clearly the US does not want another nation interfering in our politics. In only stands to reason that other nations do want the US interfering in their politics. The US may have good intentions, but other nations will not see it that way.