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Submission + - Computer-Designed Enzymes may provide help for Celiac Disease (acs.org) 2

tbg58 writes: An article in the Journal of the American Chemical Society describes how researchers used computers to modify the structure of a naturally-existing enzyme to target the immunogenic peptide implicated in celiac disease.

"The application of computational protein design tools has been demonstrated to introduce functional properties beyond those obtained by natural evolution, such as producing enzymes that perform functions not found in nature, altered specificity of proteins for their binding partners, and the de novo design of fold topologies"

Researchers report the use of computational protein design to engineer an endopeptidase with the desired traits for an oral enzyme therapy (OET) for celiac disease which not only targets the desired peptide, but is also resistant to digestive proteases and the acidic environment of the digestive system.

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