In my case, I consider a numpad-less keyboard is an optimal design. I detest number pads (and caps-lock keys but that's a whole other story) with a burning passion. Way back when, that's why I bought a Happy Hacker keyboard (PS2 interface, sadly). The gap between the keyboard and the mouse is annoying and physically bad for your body (though it may be fine for left-handed mouse users?). For same number of folks that do number crunching enough to actually need a numpad more than they need comfortable text typing, I wish the market would make standalone usb numpads more popular. They're ideal: pull one out when you're number crunching, puss it back when you're not.
"There is nothing new under the sun, but there are lots of old things we don't know yet." -Ambrose Bierce