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Comment What's normal? What's low when you are 60? 70? (Score 1) 138

Part of the problem with TRT is the definition of low tester one is somewhat nebulous. I am not sure there has been a lab range accepted age-adjusted testosterone levels. Typically the most commonly accepted medical reason is when a man comes in with a non-typical fracture (hip, vertebral body etc...) then we tend to look at testosterone levels.

Other than that...indications for use are sketchy.

In addition, anyone who has been around and doesn't have an agenda or bias would be wise to remember the fiasco with ERT in women. Made them feel good, but ended up being more harm than benefit. It is likely, outside of a few indications, that TRT will end up being the same.

Comment Confidence Intervals... (Score 1) 90

Pooled effects showed that vitamin B supplementation (including B6, B8 and B12) reduced psychiatric symptoms significantly more than control conditions [g = 0.508, 95% confidence interval (CI) 0.01–1.01, p = 0.047, I2 = 72.3%]. Similar effects were observed among vitamin B RCTs which used intention-to-treat analyses (g = 0.734, 95% CI 0.00–1.49, p = 0.051).

The confidence interval indicates the level of uncertainty around the measure of effect (precision of the effect estimate). Confidence intervals are used because a study recruits only a small sample of the overall population so by having an upper and lower confidence limit we can infer that the true population effect lies between these two points. Most studies report the 95% confidence interval (95%CI). If the confidence interval crosses 1 that implies there is no difference between arms of the study. As far as I can remember.

Comment I almost bit for one reason, gaming. (Score 1) 399

But not for the reason you might think. I'm really not that into 3D games, however full screen co-op, "dual play" or something, is a really great idea. I just don't like split-screen gaming and I wouldn't mind wearing glasses to achieve it, if needed. The drawback of course is frame rate, it should be (game_rate/2). Anyway never did and I'm not sad because of it.

Comment I'm a US doc (MD) (Score 1) 105

but I am not a neurologist. I started medical training (med school in 2004) an dI'm in practice today. I have long been suspicious that most dementias that we are calling "Alzheimer's" dementia are really multi-infarct/vascular dementia from mini-stroke/strokes/atherosclerosis etc.... Remember the "gold standard" in a practical sense to diagnose Alzheimer's demential is post-mortem brain pathology examination.

Comment Re:Right. (Score 5, Interesting) 222

I'm a doctor - MD type. I can't take a pen or a lunch without being accused of having a terrible bias and being "on the take" with "big Pharma" but politicians can literally take tens or even hundreds of thousands actual US dollars (maybe millions) then write (or have written for them) clearly bribed legislation and this is normal. Hmmmm.....

Comment Re:Not Causal (Score 1) 311

Well, that is one very cynical view. Of course they might have reasons that benefit users. The fact that they offer an adapter rather dispels this theory. Get good Bluetooth headphones and you won't want to go back. Hint: x.

Not only offer but include it in the box for "free". Apple has been known to pull of some "interesting" things with adapters before like, you need an adapter, buy it. In this case, I was pretty surprised (pleasantly) that they include the adapter.

Comment Met him at University (Score 1) 41

I had the honor and privilege of meeting Dr. Zewail and attending a private lecture while at university. His daughter was my upper division biochemistry professor and he was kind enough to drop in and give us a lecture while he was visiting. He was a brilliant thinker not just in the world of femto-spectroscopy, but overall. He was approachable and witty. He will be missed as a father, a fellow human and for his contributions to the scientific world.

Comment Now it makes sense... (Score 1) 158

I can see now why Nintendo has been so far hesitant to allow their franchises (old games specifically) to be ported to iOS or Android. There is a lot of money on the table and I think they know this. So I think we will see this portable NX feature a fair amount of retro gaming. This, in addition to the mini-Nintendo they are about to release. Except I can't imagine anyone carrying one around around in addition to their smartphone.

Comment Re:This is what happens when you have (Score 3, Informative) 193

In terms of energy efficiency, it is smart. The rate at which your house warms and cools, especially as a function of outside temperature, is a much better algorithm for controlling a heating and cooling system. However, I admit even as a gadget geek with some superfluous income it just isn't $250 cool, to me. Purely a values thing. I'd definitely be in for $150, maybe at $200. Price point is just off for what it does.

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