The answer is simple
Will Linux run out of the box on this hardware: probably yes
Will Linux run well and completely and fully utilise all the features of this hardware : probably no
An example is graphics cards, almost all are supported out of the box (more than Windows 7 supports), very few are supported with full 3D acceleration (The ones that do support 3D acceleration do so only with an extra binary driver)
VMS is like a nightmare about RXS-11M.