I think a lot of FPS players are going to be tricked into buying this ("Wow! Look at those graphics/setting/review score/whatever"), and be very distraught once they learn that it is not an FPS. Sure, there will be those who will like the fact that your shooting skills/power are based upon your stats, but I can see those who are used to guns doing a set amount of damage with a set amount of accuracy being very turned off by this game.
You know, I've heard crap like this before and I'm tired of it. FPS players play games from other genres too. We're not all obnoxious 13 year olds who think Counterstrike is the end all, be all. Most of us have longer attention spans than you give us credit for. We can read where it says 'RPG' on the fucking game box and comprehend that it isn't going to be like CS or Quake. Stop looking down at FPS players like we're retards just because we like twitch games. Very few FPS players are going to be "tricked" into buying Fallout 3.
Personally, I think the game looks great and I hope that it plays great. The post-apocalyptic wasteland looks awesome and I think they captured most of the "feel" of Fallout. I loved Fallout 1 & 2, and while I know this game won't be like those, I'm optimistic that this game could be just as excellent. I see a lot of complaints about the new AP system and the character modeling/animations, but we won't know how much those affect the fun and immersion without actually playing the game. After reading a few message boards, I feel like I'm one of the few Fallout fans that are willing to give Bethesda a chance.