That's what I've been doing, currently.
At home, I have an old razr diamondback for my right hand. At work, I have a kensington expert mouse on my left.
Seems to do a decent job of it, but I've been finding the low profile razr bothering me lately. I want to rotate my hand 90-degrees, like shaking hands. Which sucks, because I had gotten the razr because it seemed to be (at the time) the only mouse with a shape that didn't cramp up my hand.