That guy misses the point.
There is an apparent change here, evidenced by the fact that new tests of old drugs are giving poorer relative results while giving similar absolute results.
It may be due to better testing methods. It may be that there was fraud in the earlier tests which has been gradually weeded out. It may be that people in studies are culturally more eager to please and so are (consciously or unconsciously) making larger lifestyle changes when they enter the study. It may be (as stipulated in TFA) an increased confidence in pharmacology leading to a larger impact of those "other less clear and tangible effects" that PalMD nods to. It is not simply representative of the failure of pharma to find worthwhile new drugs - the fact that old drugs wouldn't pass muster puts the lie to that. What is interesting is that standards have implicitly risen, and no one understands why. This is news, this is interesting, and this should be investigated.