And how do you keep the connectors from being miswired?
By making them asymmetrical. USB is a good example. You cannot insert it upside down, and the device and host have different connectors. To connect USB wrong would require malicious intent rather than mere passive stupidity. The only time I have seen people screw it up is when they have non-standard connectors, like Apple's original iPhone connector (which Apple has now improved).
Magical thinking and 20/20 hindsight?
No, foresight and good engineering. Any engineer designing safety critical systems should be thinking: I there any way a poor trained, apathetic, low IQ, sleep deprived, color blind technician, who had an argument with his wife last night, just got chewed out by his supervisor, and is working a a cold dim hanger with gloves on, could screw this up?