I disagee. It's going to be software that replaces knowledge/information workers.
Software tools like NTT's new multi-lingual translator (real-time translation for phone conversations) are going to replace millions of jobs. Many financial newspaper articles are now entirely computer generated.
Software is very close to being able to understand, act on, and produce freeform language. Imagine a Wolfram Alpha that actually works (answers what you meant to ask) and has access to all of the data in your business empire.
Anybody that works at a desk pushing information around (accountants, lawyers, secretaries, call center, human resources, middle management, project management, reporters,