Well, we could still work to try to lessen/minimize the damage and instability.
Like, if you had gangrene on your arm, and the doctor announces, "I'm sorry, but we can't save the arm, the damage is irreversible," you wouldn't go, "Ah, well. It's impossible to save the arm. Time to wait it out and adapt."
At least, I'd hope you wouldn't. That's when you have an operation, try to save as much of your arm as you can. And then you think about what caused the gangrene in the first place, and try to not do that ever again.