Roundup has been in use for as long as I can remember, 40+ years. It's great due to it's ability to kill a plant completely and then breakdown in the soil to inert ingredients. But I have to wonder if part of the problem with the weeds becoming resistant is due to the bacteria used to make the roundup ready crops. Seems that it's more possible for a bacteria to be passed from one plant to another, and since the first resistant strain was found in 2000, there has been ten years for the bacteria to spread to other weeds.
Perhaps it's time to not create crops that are safe to spray with herbicides and just find a better way to weed the farm by machine. Perhaps after harvest and just before planting a farmer could spray the fields with roundup and kill any weeds. Then after a couple of weeks, plant the seed and while waiting for the crops to grow, a new line of machine could be built that would make it possible to weed out any non-crop plants. In the long run it would be cheaper for the farmer since a machine would be cheaper to reuse than the high cost of roundup ready seeds, and the cost of spraying once the crop is growing.
It's a great product and I've used it myself for home use for over 35 years.
Just wish I could get my wife on board with its use. She feels I have a heavy hand with it.