I'm not the GP, and I can see he used "low profile title" to mean the games that just barely make it to the shelves of physical stores, without any serious advertising campaigns etc. Those games are still built with serious budgets and 100+ person workforce and have to compete with the high-profile games. To just break even, those games need to sell in the 100K+ units scale. These are the games that, according to the GP, are going to be hit the hardest by copyright infringement.
Indie games are done in teams of maximum of 10 people, in some cases only one, where sales amounts of 5K - 10K units might (maybe) be enough to make it worth the developers' time financially speaking. These are the games which "are probably not going to be popular enough to attract that much piracy."
...yes, I pulled the numbers in this post out of my ass, but I honestly see them as somewhere in the correct ballpark. Feel free to correct me with solid information if you have any.