I had a second generation Acer Aspire One and moved to a Lenovo X120e. The SSD I was using in the Acer survived the move and is still stable. If I'd ever moved my video collection from DVDs and streaming I'd run into space trouble, but I can live within the 128 gigs the SSD leaves me with plenty of comfort.
My three big concerns are battery life, time to wake, and time to launch new applications. I spend a lot of time moving around campus and every second faster the laptop wakes up is more time I have before I have to get my A game on. The biggest speed difference I've noticed with the SSD is using Adobe Lightroom, but its still nice to bring up Firefox, Word, and Power Point faster.
The thing I love about the E-350 is how well it sleeps. I don't hibernate or use virtual memory due to the write cycle lifespan limit on SSDs, but damn AMD fusion sleeps well. Being a graduate student I've seen my current setup against student's, classmate's, and faculty's setups (overwhelmingly MacBook Airs and iPads this year). It is competitive against anything anyone else in the classroom uses. When the warranty on the SSD quits I might be scared, but right now I am enjoying it.
Right now I feel more limited by the E-350's ability to only use single channel DDR3. My documents are backed up on a form of media and my documents live somewhere in the cloud. It feels like I have the best of the mobile and desktop worlds for the tasks I need the notebook for. This would change though if I needed to edit video or compile code on the mobile.