I have a series of 4 tests to block spam on my website. So far it has stopped over 30,000 attempts in the last year.
Test one is, does the last name = the first name. For some reason almost all spammers do this.
Second, do they use a keyword from a list of about 15 words.
Third, do they fill out a hidden inputbox? This is sort of the reverse captcha.
Finally do they use more than 4 "http" in a post. Almost all comment spam is an SEO effort to increase their pagerank.