I run around 25-35 miles a week. Almost every day. I started getting serious about it halfway thru the pandemic. It has done wonders for my well-being. My slow weight gain thru adulthood accelerated the first year of shutdown, and I felt like shit. I probably briefly crested into BMI-defined obesity. I started by riding an indoor bike and slowly introduced running, then slowly ramped up mileage the last 20 months or so. Lost about 20 lbs so far and could probably lose another 20. Itâ(TM)s become an enjoyable habit/hobby, but itâ(TM)s tough to make time for it. The hardest part is starting, and then starting after stopping due to life (travel, work, family, illness). A lot of it is mental. But I know I feel my best when Iâ(TM)m exercising nearly every day, so that motivates me. And not just physically, but mentally and emotionally.

The only thing ignorant here is the general tenor of your comment. It presumes that companies will respond if you leave them. Unspoken is that this requires Nâ1, which is rarely the case. See: cell phones. With limited options, companies have little incentive to compete by not imposing such a lucrative revenue stream.

Yes, the EPA accepts campaign contributions, even thought 99.9% of its employees are civil servants. Itâ(TM)s all part of a big conspiracy led by George Soros and Big Water. Thanks, Billy Madison.

...the new family tree hints that humans first arrived in North America 56,000 years ago, much earlier than is currently estimated...

That is why. That is not what the article says, nor the commentary on the article. It's what a major news site said, probably because they employ journalists who are scientifically illiterate.

This paper stands in direct opposition to everything you are citing. Sure thereâ(TM)s likely contribution to the Homo sapiens genome from outside of Africa, eg homo eructus or Neanderthals. But the overwhelming majority of our gene pool originated in Africa, likely East Africa, and that is where most of it came from tens of thousands of years ago. There are multiple lines of evidence for this, including genetic, linguistic, and archaeological data. One only needs to look at the age and prevalence of artifacts, the number of languages and their variety, and the diversity in genetics to realize this.

Yup. I have access to Science, hence my original comment. I already had read TFA.

Ancestors distinct 56kya. Not in the americas. Slashdot, vet these posts, this sounds like a copy paste from a major news site who also got it wrong.

This is why we have epidemiologists, biostatisticians, and data scientists. We might not account for every variable, but we can say with great confidence what the uncertain term is, and focus on the 1st and 2nd order terms that matter.

Looking at it from a population health perspective, I remain skeptical that these tests will tell us more than say a PSA test, which while sensitive is not necessarily specific.

Maybe. Metabolemics is a bit of a buzz term IMO. Low SNR, machine learning based diagnostic assays, ugh. Plus non-specific: where is the cancer? How do you treat something where standard of care is chemo, radiotherapy, surgical resection, without anything big enough to show up on imaging? How do you validate this tool? Seems like a solution in search of a problem in part. Maybe it could lead to some interesting trials if it detects something normally incurable very early on like GBM and you carpetbomb with chemo. Otherwise, Iâ(TM)m not holding my breath.

Let the physicists take it. They'll probably flunk out the emotional processing tests and ace the rest.

@AC: bullshit. the loudest bitchers are the people practicing quackery masquerading as scientists. Why believe me? Because I'm peer-reviewed, I'm peer-rejected, and I'm a peer-reviewer. Disagree? Go get a PhD, post-doc, publish a bunch of papers, and get involved through volunteerism to enter the system, and then tell us from the inside how you feel.

I don't think it's pay-to-play, but if this were something truly ground-breaking, I'd expect a higher profile journal with a more rigorous review process.

PhD physicist here. Sounds like poppycock. If it's real, publish it in Nature, Science, or the like.

Also, it's spelled "douchebag".

... so you're teaching premed students? ;-)