Perhaps.
I grow Carolina Reapers. I do not eat Carolina Reapers.
Well, I mean, I do eat them: I blend them with a lot of salt and plenty of strong vinegar and freeze them in squeeze-bottles until it is time to consume. The mixture seems to keep indefinitely, once thawed, under normal refrigeration.
I've also fermented them and done the same sort of thing with them, which produces very different taste.
The sauce is a crowd pleaser and it is very tasty. But despite being made from the hottest of peppers, I've had it described as being "surprisingly mild." In sauce form, it's easy to use tiny amounts.
But I don't eat them. I've chopped up tiny slivers of one and put it on a baked potato (with plenty of butter, sour cream, and cheese), many times, and I ate those potatoes, but I don't just -- you know -- eat them as they are.
Eating these peppers as they are is a really fucking stupid thing to do. Then-girlfriend's much-younger then-high-school-aged brother liked to take them to school with him; I encouraged him not to. He used them as dare material. I feel bad for those poor bastards.
These fuckers are mean. When I had a surplus of some of these and some other scary-hot peppers one year (more than I could bottle), I tried to give some to the Asian grocery store next door who was always kind to me, just a basket on the counter of peppers for folks to -- you know -- just take for free. "Too hot," they said after a couple of days. "Nobody wants these," they added when they gave them back). A bunch of spicey-food-loving Mexicans that my Dad knows also rejected them ("too hot," they said too)..
And yes, it's "all in your head," but the body's reaction to what's in your head can be very damaging to said body.
That all said: I'm lead to wonder if the "thunderclap headaches" in TFA weren't caused directly by the violent retching. The human body is pretty fucking hard on itself when it comes to expelling (what it considers to be) poisons.