If you are using 64-bit Windows you can forget syncing by USB. Some individual apps like pocket tunes (pTunes) will still sync since they identify as a different device altogether. If you sync by bluetooth, infrared, or serial (even through a USB converter) everything will work fine, but slowly. Palm is not updating their software and drivers to work on 64-bit Windows and the official solution is to use either Bluetooth or Infrared to sync. 32-bit Windows up to and including Windows 7 will work with the Palm Hotsync software, but with 64-bit there is simply no USB driver. I don't think Palm will discontinue the Centro anytime soon, nor any of their standalone PDAs that still use Palm OS. They need to re-write their software to support 64-bit Windows and Mac OSX on Intel in both 64-Bit (and if necessary 32-bit).