withdrawal presents as a rapid, dysphoric return of depression symptoms—perhaps worse in intensity than their initial/untreated state?
Initially yes. I wasn't expecting it but I caught myself being very emotional and realized that must be what it was. It leveled off rather quickly. The Wiki in my OP explains how 5-HTP is able to absorb into the brain and become 5-HT or Serotonin. Interestingly 5-HT cannot be absorbed into the brain. Since Serotonin is linked to mood it makes sense an increased level would have a positive effect.
Interestingly 5-HT cannot be absorbed into the brain. Since Serotonin is linked to mood it makes sense an increased level would have a positive effect.
I was surprised to see that 5-HTP is categorized as a sleep-aid anda nootropic, what with the former class being generally dominated by stimulants.
I'm actually replying because I neglected to mention my main reason for speculating that the crash was fast and severe: Unlike SSRIs with their multiple-week delay before they (are supposed to) become effective, and bupropion (which has a somewhat quicker, but rather subtle effect), imipramine is profoundly effective beginning on day one. Sometimes when I get to the end of the Rx and I don't feel a sense of urgency (or I'm just unable to get to the pharmacy)... If it slips my mind during the subsequent few days, I experience a very nasty reminder—the speculative description I asked you to confirm hits me like a bolt from the blue—one second I'm fine, the next I'm tearing up and wishing for a real bolt from the blue. Once I get it again, though, its full effect is restored in less than one hour.
My apologies if my wordy anecdote lacked substance... I was skeptical of swalve's warning, and was curious if sudden cessation of a naturally-occurring dietary supplement could actually slap down a patient as hard as a severe, 60-year-old Rx. :o) Thanks for reading and for your reply.