Lightening even.

I don't know, with that tin foil hat maybe you should be more worried about lighting too.

Any takers on how many trojans/rootkits this guy is hoarding?

To scan 200,000 lottery tickets and sort out the winners.

There != their

You clearly misunderstood the post you're responding to, or are yourself, an

The poster implied that he would sell the rights to a pharma company and indeed licensing compounds from smaller companies/research labs is indeed standard practice. If you meant that the pharma companies don't have enough new drugs of their own, this is in fact wrong.

The second part of the post implied the kid would never be heard from again. If he made enough money it's possible. I'm guessing you misinterpreted this as a statement the company would buy his compound and it would never see the light of day, thus garnering your idiot comment. While it's not what he meant, it is in fact also common practice in pharma for companies to license the rights to compounds similar to those they are developing just to eliminate potential competition. It's why often when licensing a compound stipulations are added that the purchasing company must intend to develop it.

All of this is likely moot as the kid does not own the rights to the compounds. TFA doesn't specify whether they are novel but my guess would be he worked with a library of existing compounds that showed some activity against cystic fibrosis in preliminary screenings.

Okay, we'll be Planet A and you can be Planet 1.

Come on google, enough bullshit. Leave the non-critical tweaks until after you've fixed the goddamn "print selection" option.

I'm not sure I quite get the analogy. Can you explain it again using cars this time?

One of the problems with warfarin is that there is a lot of variability between patients. The main clearance enzyme for warfarin, CYP2C9, has reduced function in around roughly 25% of patients due to genetic polymorphisms. The target for warfarin, VKORC1, is highly variable due to genetics and the substrate concentrations, vitamin K, can vary greatly with dietary intake. Warfarin also has a narrow therapeutic window. If concentrations are too high there can be bleeding problems and at concentrations too low it's ineffective.

The end result is that the initial warfarin dosing can be extremely variable and requires close therapeutic monitoring when starting a new patient on the treatment. It's a far cry from something like aspirin where there is a pretty good idea of what dose a patient will need. A drug company producing something similar to warfarin that wasn't subject to such high genetic variability would be clinically preferred due to lower health care costs in starting treatment on new patients. That said, when you're properly dosed warfarin is pretty damn effective.

I hear you. Ex-geek squad here. I was never able to look someone in the face and tell them yes, you really should pay us $29 to install that ram for you.

The most egregious markups are on the accessories. Look at the $25 USB printer cable or the $30 HDMI cable. They don't have to make the profit on the big ticket items if they can milk you on all the little things that go with them.

It was 6.x (don't remember the rest off-hand but can check later) on my work laptop. I was going to complain about it not existing but when I went to double check it was mysteriously there. Now at home on my desktop with 7.0.517.41 it's nowhere to be found.

Chrome just got the print selection option (which I didn't realize was silently added until just now).

Long story short, don't. It's not worth the risk. To "synthesize" your own you would need to obtain an isolated DNA sequence for insulin and transfect it into a cell line. Then culture the cell line and purify the insulin from cell products, most likely with some sort of chromatography. That said, this is not something you're going to easily accomplish at home. Producing proteins is not like making small molecule compounds. With small molecules you either have it or you don't. It isn't so cut and dry with proteins. Even a product of the same amino acid sequence can vary greatly in the post-translational modifications it undergoes. Prokaryotes don't glycosylate proteins and yeast hyperglycosylate is just one example. That's not to mention contamination from denatured protein and aggregates. Even if you did manage to create insulin, you would have to be crazy to think about injecting it into yourself. The purity is going to be dubious at best and you run the risk of developing an immune response to it. Worst case scenario, those antibodies are cross reactive to your body's endogenous insulin and you're now not only under-producing insulin, your body is attacking the little that you do make (or inject).