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Biotech

"Normal" Prions May Protect Myelin 81

thomst writes "Nature Neuroscience just published an online article about the function of 'normal' prions in protecting myelin, the substance that sheathes and protects sensory and motor nerves. The international study (which has 11 authors) concluded that 'normal' (i.e., not mis-folded) prions may form a protective coat around myelin. The researchers found that Prnp -/- mice (mice with the gene for prions knocked out) consistently developed progressive demyelination, inevitably leading to persistent polyneuropathy by 60 weeks of age. Their data suggest that damage to myelin sheaths cause normal prions to cleave, and the resulting prion fragments activate Schwann cells, which are known to play a part in myelin repair. This research might eventually lead to possible treatments for progressive polyneuropathies in humans, including those mediated by Creutzfeldt-Jakob disease, multiple sclerosis, Alzheimer's, and even diabetes."
GNU is Not Unix

100% Free Software Compatible PC Launches 458

crimperman writes "The Open-PC project has announced that its first PC will be available at the end of February for €359. They claim the mini-ITX desktop machine is energy efficient, consumer ready, easy to upgrade, and — significantly — uses only hardware that has free software drivers available. As you'd expect, it comes with GNU/Linux which is running KDE (a €10 donation to the KDE project in included in the price). Interestingly all the key decisions on design, pricing etc. have been made by the community via online polls. The spec of the machine is pretty reasonable for the price: Atom 1.6GHz dual-core processor, 3GB RAM, 160GB HDD, Intel 950 graphics."
Nintendo

Nintendo Shuts Down Fan-Made Zelda Movie 222

Andorin writes "An independently filmed adaptation of The Legend of Zelda: Ocarina of Time, called The Hero Of Time, has been taken offline by Nintendo as of the end of December. The film's producers write: 'We came to an agreement with Nintendo earlier this month to stop distributing the film... We understand Nintendo's right to protect its characters and trademarks and understand how in order to keep their property unspoiled by fan's interpretation of the franchise, Nintendo needs to protect itself — even from fan-works with good intentions.' Filming for the feature-length, non-profit film began in August 2004 and the movie was completed in 2008. It premiered in various theaters worldwide, including in New York and Los Angeles, and then became available online in the middle of December, before it was targeted by Nintendo's legal team. As both an avid Zelda fan and an appreciator of independent works, I was extremely disappointed in Nintendo's strong-arming of a noncommercial adaptation to the Game of the Year for 1999."
Cellphones

Cell Phone Searches Require Warrant 161

schleprock63 writes "The Ohio state supreme court has decided that a cell phone found on a suspect cannot be searched without a warrant. The majority based this decision on a federal case that deemed a cell phone not to be a 'closed container,' and therefore not searchable without a warrant. The argument of the majority contended that a cell phone does not contain physical objects and therefore is not a container. One dissenting judge argued that a cell phone is a container that simply contains data. He argued that the other judges were 'needlessly theorizing' about the contents of a cell phone. He compared the data contained within an address book that would be searchable." The article notes that this was apparently the first time the question has come up before any state supreme court.
KDE

What's Coming In KDE 4.4 423

buzzboy writes "If you're wondering what the folks over at KDE have been cooking up for the next major release, KDE 4.4, well, quite a bit as it turns out. In a lengthy interview, KDE core developer and spokesperson for the project Sebastian Kugler details the myriad changes that are coming with the 4.4 release — the fifth major release since KDE 4.0 debuted to much criticism nearly two years ago. The project has closed about 18,000 bugs over the past six months and the pace of development is snowballing. The 'heavy-lifting' in libraries and frameworks for 4.0 is now starting to pay off. Perhaps the biggest change is in the development of a semantic desktop. According to Kugler, 'If you tag an image in your image viewer, the tag becomes visible in your desktop search. That's how it should be, right?' There is also a picture gallery of KDE 4.4 (svn) screenshots so you can see what it will look like."
Spam

Researchers Take Down a Spam Botnet 207

The Register is reporting on the takedown of a botnet once responsible for 1/3 of the world's spam. The deed was done by researchers from the security firm FireEye, who detailed the action in a series of blog posts. PC World's coverage estimates that lately the botnet has accounted for 4% of spam. From the Register: "After carefully analyzing the machinations of the massive botnet, alternately known as Mega-D and Ozdok, the FireEye employees last week launched a coordinated blitz on dozens of its command and control channels. ... Almost immediately, the spam stopped, according to M86 Security blog. ... The body blow is good news to ISPs that are forced to choke on the torrent of spam sent out by the pesky botnet. But because many email servers already deployed blacklists that filtered emails sent from IP addresses known to be used by Ozdok, end users may not notice much of a change. ... With [the] head chopped off of Ozdok, more than 264,000 IP addresses were found reporting to sinkholes under FireEye's control..."
Security

Now Linux Can Get Viruses, Via Wine 343

fsufitch writes "Wine has advanced enough to make Linux not immune to Windows viruses. However, just like many Wine applications, it takes a bit of effort to get the program off the ground. Also, just like some Windows programs running via Wine, not all features may work — in this case, the crippling of the system, immunity to the task manager, identity theft, etc."
The Courts

Data Entry Errors Resulted In Improper Sentences 138

shrik writes "Slate has a look at the efforts of Emily Owens, in 2005 a Ph.D student in economics at the University of Maryland, who 'came across thousands of inconsistencies and errors in the sentencing recommendations provided to judges' by the Maryland State Commission on Criminal Sentencing Policy. Quoting: 'The sentencing guidelines for judges were based on a work-sheet [PDF] that "graded the severity of a convict's crime and his risk to society", ostensibly to make the rulings meted out more objective in nature. But on carefully studying her data, Owens noticed something wasn't adding up — the system seemed to be producing 1 error in every ten trials. She also realized that this "recommendation system" actually mattered: crimes and criminals analyzed to be quite similar were resulting in systematically different punishments correlated with the work-sheet.' The source of these discrepancies was ultimately found to be a simple, but very significant, PEBKAC: 'More than 90 percent of errors resulted from the person completing the work sheet [usually the DA, but signed off by the defense attorney] entering the figure from a cell next to the correct one. ... The remaining errors came mostly from incorrect choice of criminal statute in calculating the offense score and from a handful of math errors (in operations that were literally as simple as adding two plus two).' Timo Elliott's BI Questions Blog lists the morals of the story."
Linux

PulseAudio Creator Responds To Critics 815

Dan Jones writes "As recently discussed here, Linux sound development has come under fire for being overly complex and, more specifically, PulseAudio has been criticized for not being a 'good idea.' In a lengthy interview, PulseAudio creator Lennart Poettering has responded to the many critics of the new-generation sound server and says such complaints and criticisms about PulseAudio in some Internet forums are not really shared by the vast majority of technical people. While Poettering admits PulseAudio itself is not bug-free, he believes the majority of issues are being triggered by misbehaving drivers or applications."

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