Gerard Pinzone writes: "A drug that exploits the benefits of a component in wine proved safe and showed signs that it might improve blood sugar control in people with the most common form of diabetes, Sirtris Pharmaceuticals Inc said on Monday. The compound, dubbed SRT501, can be absorbed in the body more easily than the red wine compound resveratrol, the company said." While this particular study involved diabetes sufferers, the goal is to mimic the beneficial effects of calorie restriction without dieting. (A Slashdot worthy article indeed!) "Mice on a high-fat diet and treated with resveratrol also performed better than untreated mice at a similar weight in an endurance test. The drug treated mice ran almost twice as far in a treadmill exercise test compared to the placebo group." Click on the 'Mouse Marathon Video' link to see the results.