Computational Simulations of E.coli 51
Gearoid_Murphy writes, "BBC news has the story of a scientist who has been using computational models of bacteria to advance our understanding of actual bacteria — a step towards simulating fully fledged organisms in virtual environments and potentially an extraordinarily powerful tool for medical science."
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I wouldn't mind Heaven if I could go grab a beer and some bowling with God.
Say what? (Score:2)
So the story is a simulation that actually simulates what it's simulating? (Isn't that what a simulation's suppose to do? Model and echo what happens in the real world)
How stimulating.
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*yawn*
Let me know when he gets *results*. Anyone can "make a model".
Anyone can "make a model". (Score:2)
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(1) You have to know which pieces you can simplify how, and doing so shows you what's important and what's just details.
(2) You can actually analyze a simple model to see if it predicts things you didn't learn from dir
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Sort of like physics; every discovery in physics is always about how our understanding of the universe is approaching correctness.
A lot of models don't work. A lot of simulations are broken either because they are wrong, too simple, or irrelevant.
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Imagine if you didn't know how a computer was constructed, other than knowing it was composed of millions of transistors, resistors, capacitors, and other electronic components. Now imagine having simulated transistors, resistors, capacitors, and other electronic components. How difficult would it be (not knowing how a computer is constructed) to put together these simulated
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The Matrix! (Score:3, Insightful)
Hopefully this would eventually allow risky medial treatments to be simulated before they have to be performed with a scan of the patients physiology as a reference.
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Intelligent design is not creationism. Creationism implies "poof, humans exist because God says so". Intelligent Design says "Evolution occurs because it was guided by God to give humans as the final outcome". I think ID is a much more sensible idea than Creationism and, inevitably, will be what the church adopts, just as they, eventually, adopted the idea of a Copernican universe, despite long, long years of keeping an Aristotlian view.
ID doesn't
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Re:The Matrix! (Score:4, Interesting)
Hopefully this would eventually allow risky medial treatments to be simulated before they have to be performed with a scan of the patients physiology as a reference.
The scientific community is already working on it, as you might well imagine. Take a look here [pathguide.org] for a list of published databases of protein interactions and metabolic pathways. The drug companies are throwing money at developing systems that can use this sort of data to (for example) predict negative drug interactions well before a new drug gets anywhere near clinical trials. They're also being used to better understand exactly how existing drugs work, trying to isolate causes of desired effects from those of side effects. This is an emerging field, applying well studied (in computer science) principles of graph theory to biological networks that are only now being mapped.
-JMP
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Does this simulation also include... (Score:3, Funny)
I dont care what the computers say..... (Score:1)
What next? Is some bored dude going to do a computer model on just what is it that makes Anna Nicole Smith stupid?
I dont know about you, but when do we get the computer models showing exactly why Guinness tastes better than Budweiser, so someone can share that data in time to save me some damn money?
Need to know basis. (Score:2)
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If the simulation framework would already exist, you would be right, but in the particular case you mention you're probably not: you'd have to first find out which receptors in the tastebuds are responsible and what their structure is. To be honest, computer simulation is still far away from such amazingly complex tasks.
Furthermore changing a beverage can be done fairly cheaply, you just
Can this article be more dumbed down? (Score:3, Insightful)
Wow, that kinda sounds like.. umm, what's the word I'm after here, umm, science, yes, that's it.
Article short on details, but interesting (Score:3, Insightful)
The professor used this analogy: think of filling a football/soccer (your choice) stadium with ping-pong balls, and paint just two of those balls orange. Then hire some bulldozers to push the balls around randomly and continuously for several decades. How often will the orange balls collide with each other? Once a week? Once a month? Once a year? Maybe only once in a decade? Now envision the stadium scaled down to the size of a cell, with the ping-pong balls now being your average-sized molecule important for some process (chunks of amino acids, say). These will be moving around randomly due to Brownian motion, chemical gradients, etc. How often will two given molecules interact? Probably several times per second. THAT's how amazingly extreme cellular processes are.
It's that sort of analogy (sorry it wasn't about cars, but we could probably work those in somehow) that the article should have had. This stuff is complicated, and requires VERY efficient computation. Kudos to the researchers, and pfft! to the author of the article.
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Who let you out of the Tofu factory? (Score:1, Troll)
Here is a clue, hippie: Find something else on which to base your self-esteem.
Now, get back to the line, and don't forget to bag your sandals.
LOL (Score:3, Interesting)
I've had E.Coli (Score:2, Funny)
I know why (Score:2)
ten year old news (Score:1)
A step? (Score:1)
Yeah but it's like, a really small step isn't it? You couldn't do anything useful with it except maybe simulate Dubya's cerebral activity, and that's not very useful at all.
And besides, didn't you hear: Virtual Environments/Machines are going to be banned on Vista!
Sounds interesting, but don't jump the gun (Score:2, Informative)
I don't know this research, and the article doesn't really say anything at all, but as a grad student who has done a lot of cell modeling research, I like his approach of limiting the model to something very simple and easy to verify. We are a long, long way off from "simulating fully fledged organisms in virtual environments". Probably not in our lifetimes. You just have no idea how complex even E. coli is until you study it, and if you have, you'll understand how primitive and limited our models are.
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Greg Egan's Permutation (Score:1)
Hard-scifi, check it out!