Here's a suggestion: When moderating, set to -1, Newest First (Ignore Threads).
Why? In reading /. articles it usually turns out that the highest rated comments are near the beginning, or replies to posts near the beginning. So if someone comes along later and posts something especially insightful or funny, he has almost no chance of getting modded up. That is, unless you read in reverse chronological order. Then these people will have a better chance of being modded up (or down, as the case may be).