I started to work on an indy game. Here is what I am using : irrlicht for graphics, open dynamics engine for physics, audiere for sound. I plan on using raknet for multiplayer if I can figure it out - and I might end up using SDL for joystick support (but I have not done much research into it yet). Blender to make the 3d models, the gimp to make the textures, kdevelop to code in.
I don't know what I have to use to make the game work on a mac - but when it comes time to dust off my spare PC and make a windows build, I'll go with devc++.
As for the game itself, it is a first person 6dof space shooter w/ zero-g physics. The goal is to make the most realistic space shooter possible.
I'll put a demo up on Happypenguin.org when it becomes a bit more playable.