tguyton writes "The good news: the FDA just approved the distribution of the first drug to treat the underlying cause of Cystic Fibrosis, called Kalydeco by Vertex Pharmaceuticals. The bad news: this drug will only affect 4% of patients with the disease in the U.S. From the article: '[Affected patients] with the so-called G551D mutation have a defective protein that fails to balance the flow of chloride and water across the cell wall, leading to the buildup of internal mucus. The vast majority of cystic fibrosis patients have a different genetic defect, in which the protein does not reach the cell wall. Vertex is developing another drug to try and address that problem. Study data for that drug is expected later this year.' Hopefully the research involved will be applicable to finding treatments for other genetic diseases." Further bad news: "...executives said Kalydeco would cost $294,000 for a year's supply, placing it among the most expensive prescription drugs sold in the U.S."

N!NJA writes with an excerpt from a post by Florian Mueller: "Barnes & Noble's primary line of defense against Microsoft's allegations of patent infringement by the bookseller's Android-based devices has collapsed in its entirety. An Administrative Law Judge at the ITC today granted a Microsoft motion to dismiss, even ahead of the evidentiary trial that will start next Monday (February 6), Barnes & Noble's 'patent misuse' defense against Microsoft. [...] Prior to the ALJ, the ITC staff — or more precisely, the Office of Unfair Import Investigations (OUII), which participates in many investigations as a third party representing the public interest — already supported Microsoft's motion all the way. The OUII basically concluded that even if all of what Barnes & Noble said about Microsoft's use of patents against Android was accurate, it would fall far short of the legal requirements for a patent misuse defense."

thomst writes "Cnet's Stephen Shankland breaks the news that Sony will replace the lamentable Howard Stringer with Kazuo Hirai, the (now former) head of its electronics division. Better yet, the changeover will take place on April Fool's Day. Stringer, who was appointed CEO of Sony in 2005, will become Chairman of its board, and Hirai will become a board member. Hirai has been the leader of Sony's consolidated electronics group only since last year. He was in charge of all Sony electronics products, including the Playstation Network, which famously suffered a massive security breach that compromised its unencrypted user data on his watch."

New submitter udas writes "Greg Kroah-Hartman, maintainer of the Linux kernel's stable branch, has left his job with SUSE Linux. He is now a fellow at the Linux Foundation. 'There were no direct conflicts working for SUSE, as the people there understand how important the individual developer, and their voice, is in the Linux community,' Kroah-Hartman told Ars this week in an e-mail interview. 'But, working in a vendor-neutral environment like the Linux Foundation allows me to spend a larger amount of time interacting with other companies and vendors, as well as helping Linux out in environments that were not necessarily the focus of my previous employer.'"

concertina226 writes with sad news for Swedish pirates. Quoting the article: "The Swedish Supreme Court will not hear an appeal from the founders of The Pirate Bay against prison sentences and fines imposed by the Swedish Court of Appeals, the court said on Wednesday. Over a year ago, the Court of Appeals sentenced Fredrik Neij, Peter Sunde, and Carl Lundström to 10 months, eight months, and four months of jail time, respectively. The court also said they must collectively pay a 46 million kronor (£4.3 million) fine." The Pirate Bay has issued a response: "With this said, we hear news from our old admins that they have received a verdict in Sweden. Our 3 friends and blood brothers have been sentenced to prison. This might sound worse than it is. Since no one of them no longer lives in Sweden, they won't go to jail. They are as free today as they were yesterday."
Update: 02/01 15:15 GMT by U L :Reader think_nix helpfully copied the Pirate Bay response in a comment for those who cannot access the site.

Hugh Pickens writes "Brian Fung writes in the Atlantic that one of Romney's electoral problems is that he occupies a kind of uncanny valley for politicians, inexplicably turning voters off despite looking like the textbook image of an American president. Just as people who interact with lifelike robots often develop a strange feeling due to something they can't quite name, something about Romney leaves voters unsettled. As with the robotic version of the uncanny valley, the closer Romney gets to becoming real to a voter, the more his likeability declines. 'The effect is almost involuntary, considering the substantial advantages Romney enjoys from appearance alone,' writes Fung. 'But in person, his polished persona gives way to what appears a surprisingly forced and inauthentic character.' Political commentator Dana Milbanks adds that although Romney is confident and competent, in casual moments his weirdness comes through — equal parts 'Leave It to Beaver' corniness and social awkwardness. 'Romney's task now is to work his way out of the uncanny valley toward a more compelling style of humanity,' concludes Fung. 'But every day he lingers in it, the hill grows steeper.'"

Morty writes "The National Science Advisory Board for Biosecurity (NSABB) has recommended that details of two research papers involving Avian Flu not be published because of security concerns. At least one of the research groups says that their work should be logically reproducible. The NSABB's censorship recommendations do not (currently) have the force of law, but Science and Nature voluntarily delayed publication."

An anonymous reader writes "Mikael Hed is the CEO of Rovio Mobile, the company behind popular mobile puzzle game Angry Birds. At the Midem conference Monday, Hed had some interesting things to say about how piracy has affected the gaming industry, and Rovio's games in particular: '"We could learn a lot from the music industry, and the rather terrible ways the music industry has tried to combat piracy." Hed explained that Rovio sees it as "futile" to pursue pirates through the courts, except in cases where it feels the products they are selling are harmful to the Angry Birds brand, or ripping off its fans. When that's not the case, Rovio sees it as a way to attract more fans, even if it is not making money from the products. "Piracy may not be a bad thing: it can get us more business at the end of the day." ... "We took something from the music industry, which was to stop treating the customers as users, and start treating them as fans. We do that today: we talk about how many fans we have," he said. "If we lose that fanbase, our business is done, but if we can grow that fanbase, our business will grow."'"

antifoidulus writes "I'm about to get my masters in Computer Science and start out (again) in the 'real world.' I already have a job lined up, but there is one thing that is really nagging me. Since my academic work has focused almost solely on computer science and not software engineering per se, I'm really still a 'hacker,' meaning I take a problem, sketch together a rough solution using the appropriate CS algorithms, and then code something up (using a lot of prints to debug). I do some basic testing and then go with it. Obviously, something like that works quite well in the academic environment, but not in the 'real world.' Even at my previous job, which was sort of a jack-of-all-trades (sysadmin, security, support, and programming), the testing procedures were not particularly rigorous, and as a result I don't think I'm really mature as an 'engineer.' So my question to the community is: how do you make the transition from hacker (in the positive sense) to a real engineer. Obviously the 'Mythical Man Month' is on the reading list, but would you recommend anything else? How do you get out of the 'hacker' mindset?"

malraid writes "The White House has issued a statement in which they refuse to comment on the petition to investigate Chris Dodd for bribery from the MPAA to pass legislation. The reason given: 'because it requests a specific law enforcement action.'"