An anonymous reader quotes a report from the Los Angeles Times: It was the late 1980s when Gary Mund felt his pinky tremble. At first it seemed like a random occurrence, but pretty quickly he realized something was seriously wrong. Within two years, Mund -- a crew worker with the Eastern Municipal Water District in Riverside County -- was diagnosed with Parkinson's disease. The illness would eventually consume much of his life, clouding his speech, zapping most of his motor skills and taking away his ability to work and drive. "It sucks," said Mund, 69. He speaks tersely, because every word is a hard-won battle. "I was told the herbicide wouldn't hurt you."

The herbicide is paraquat, an extremely powerful weed killer that Mund sprayed on vegetation as part of his job from about 1980 to 1985. Mund contends the product is responsible for his disease, but the manufacturer denies there is a causal link between the chemical and Parkinson's. Paraquat is manufactured by Syngenta, a Swiss-based company owned by the Chinese government. The chemical is banned in at least 58 countries -- including China and Switzerland -- due to its toxicity, yet it continues to be a popular herbicide in California and other parts of the United States. But research suggests the chemical may cross the blood-brain barrier in a manner that triggers Parkinson's disease, a progressive, neurodegenerative disorder that affects movement. Now, Mund is among thousands of workers suing Syngenta seeking damages and hoping to see the chemical banned.

Since 2017, more than 3,600 lawsuits have been filed in state and federal courts seeking damages from exposure to paraquat products, according to Syngenta's 2022 financial report (PDF). [...] Paraquat is 28 times more toxic than another controversial herbicide, Roundup, according to a report from the Pesticide Action Network. (Roundup has been banned in several parts of California, including a 2019 moratorium by the Los Angeles County Board of Supervisors forbidding its use by county departments.) Paraquat also has other known health effects. It is listed as "highly toxic" on the U.S. Environmental Protection Agency's website, which says that "one small sip can be fatal and there is no antidote." The EPA is currently reviewing paraquat's approval status. However, both the EPA and Syngenta cited a 2020 U.S. government Agricultural Health Study that found there is no clear link between paraquat exposure and Parkinson's disease. A 2021 review of reviews similarly found that there is no causal relationship.

An anonymous reader quotes a report from The Guardian: Marc, 63, from Bordeaux, France, was diagnosed with the degenerative disease more than 20 years ago and had developed severe mobility problems, including balance impairments and freezing of gait. After receiving the implant, which aims to restore normal signaling to the leg muscles from the spine, he has been able to walk more normally and regained his independence. "I practically could not walk any more without falling frequently, several times a day. In some situations, such as entering a lift, I'd trample on the spot, as though I was frozen there, you might say," he said. "Right now, I'm not even afraid of the stairs any more. Every Sunday I go to the lake, and I walk around 6 kilometers [3.7 miles]. It's incredible."

The implant is yet to be tested in a full clinical trial. But the Swiss team, who have a longstanding program to develop brain-machine interfaces to overcome paralysis, hope that their technology could offer an entirely new approach to treating movement deficits in those with Parkinson's disease. "It is impressive to see how by electrically stimulating the spinal cord in a targeted manner, in the same way as we have done with paraplegic patients, we can correct walking disorders caused by Parkinson's disease," said Jocelyne Bloch, neurosurgeon and professor at the CHUV Lausanne University hospital, who co-led the work.

First, the team developed a personalized anatomical map of Marc's spinal cord that identified the precise locations that were involved in signaling to the leg to move. Electrodes were then implanted at these locations, allowing stimulation to be delivered directly into the spine. The patient wears a movement sensor on each leg and when walking is initiated the implant automatically switches on and begins delivering pulses of stimulation to the spinal neurons. The aim is to correct abnormal signals that are sent from the brain, down the spine, to the legs in order to restore normal movement. "At no point is [the patient] controlled by the machine," said Prof Eduardo Martin Moraud, of Lausanne University hospital. "It's just enhancing his capacity to walk." The study, published in Nature Medicine, found that the implant improved walking and balance deficits and when Marc's walking was analyzed it more closely resembled that of healthy controls than that of other Parkinson's patients. Marc also reported significant improvements in his quality of life.

Marines and sailors who were exposed to toxic water at Camp Lejeune, N.C., are much more likely to suffer from Parkinson's disease than their counterparts who were stationed elsewhere, according to a study published Monday. From a report: Troops stationed at Camp Lejeune for even just a few months during the years 1975-85 are 70% more likely to suffer from Parkinson's disease than troops who were at Camp Pendleton, Calif., according to findings from researchers who accounted for other factors in making their determination. Their report was published by the Journal of the American Medical Association. The Department of Veterans Affairs-funded study was led by Dr. Samuel Goldman, a professor of medicine at the University of California, San Francisco Medical School and a staff physician at the San Francisco VA Medical Center.

The Departments of Defense and Veterans Affairs have acknowledged for years that troops based at Camp Lejeune and other North Carolina facilities from the early 1950s until the mid-1980s were exposed to a number of harmful chemicals in the drinking water, including the solvents benzene and trichloroethylene, which are linked to Parkinson's. Water processed for the base was contaminated by improper chemical-disposal procedures from an off-base dry cleaner, leaky underground storage tanks, industrial spills and other problems for decades, according to the Centers for Disease Control and Prevention. A million veterans and family members have been potentially affected, according to the federal Agency for Toxic Substances and Disease Registry.

Diana Kwon writes via Scientific American: A Scottish woman named Joy Milne made headlines in 2015 for an unusual talent: her ability to sniff out people afflicted with Parkinson's disease, a progressive neurodegenerative illness that is estimated to affect nearly a million people in the U.S. alone. Since then a group of scientists in the U.K. has been working with Milne to pinpoint the molecules that give Parkinson's its distinct olfactory signature. The team has now zeroed in on a set of molecules specific to the disease -- and has created a simple skin-swab-based test to detect them.

[...] The researchers used mass spectrometry to identify types and quantities of molecules in a sample of sebum, an oily substance found on the skin's surface. They discovered changes to fatty molecules known as lipids in people with Parkinson's. In their latest study, published on September 7 in the American Chemical Society journal JACS Au, the researchers revealed the results of using a simple skin-swab-based test to detect the lipid signature that is indicative of Parkinson's. By comparing sebum samples from 79 people with Parkinson's and 71 people without the illness, the team zeroed in on a set of large lipids that could be detected in a matter of minutes using a special type of mass spectrometry in which substances are rapidly transferred from a swab to an analyzer using just a piece of paper.

"I think it's a very promising set of biomarkers," says Blaine Roberts, a biochemist at Emory University, who wasn't involved in the work. He adds that one of the big open questions that remains is how exacting this test can be. While the authors of the September 7 study reported the detailed chemical profile of the unique Parkinson's signature, they did not include an assessment of its accuracy. According to Barran, based on not-yet-published data, their test appears to be able to determine whether an individual has Parkinson's with more than 90 percent accuracy. [...] The team is now working with local hospitals to determine whether this sebum-based test can also be conducted in clinical labs -- a key step toward determining whether it can be used as a diagnostic tool. Ultimately, Barran says, the hope is to use the test to help identify individuals who have been referred to their neurologists by their general practitioner for suspected Parkinson's so they can receive a faster diagnosis. The researchers are also working with a group at Harvard "to determine whether sebum-based biomarkers are detectable in people who have constipation, a reduced sense of smell or other early signs of Parkinson's but have not yet received a diagnosis," reports Kwon.

Meanwhile, Milne is working with scientists to sniff out people with Alzheimer's, cancer, and tuberculosis -- all of which she says have a unique smell.

An anonymous reader quotes a report from MIT News: Parkinson's disease is notoriously difficult to diagnose as it relies primarily on the appearance of motor symptoms such as tremors, stiffness, and slowness, but these symptoms often appear several years after the disease onset. Now, Dina Katabi, the Thuan (1990) and Nicole Pham Professor in the Department of Electrical Engineering and Computer Science (EECS) at MIT and principal investigator at MIT Jameel Clinic, and her team have developed an artificial intelligence model that can detect Parkinson's just from reading a person's breathing patterns. The tool in question is a neural network, a series of connected algorithms that mimic the way a human brain works, capable of assessing whether someone has Parkinson's from their nocturnal breathing -- i.e., breathing patterns that occur while sleeping. The neural network, which was trained by MIT PhD student Yuzhe Yang and postdoc Yuan Yuan, is also able to discern the severity of someone's Parkinson's disease and track the progression of their disease over time.

The MIT researchers demonstrated that the artificial intelligence assessment of Parkinson's can be done every night at home while the person is asleep and without touching their body. To do so, the team developed a device with the appearance of a home Wi-Fi router, but instead of providing internet access, the device emits radio signals, analyzes their reflections off the surrounding environment, and extracts the subject's breathing patterns without any bodily contact. The breathing signal is then fed to the neural network to assess Parkinson's in a passive manner, and there is zero effort needed from the patient and caregiver. "A relationship between Parkinson's and breathing was noted as early as 1817, in the work of Dr. James Parkinson. This motivated us to consider the potential of detecting the disease from one's breathing without looking at movements," Katabi says. "Some medical studies have shown that respiratory symptoms manifest years before motor symptoms, meaning that breathing attributes could be promising for risk assessment prior to Parkinson's diagnosis." The research has been published in the journal Nature Medicine.

According to a new study, the Apple Watch can be used to monitor symptoms of Parkinson's disease. STAT reports: Researchers at Apple, working with specialists who treat Parkinson's, designed a system that uses the Apple Watch to detect the motor symptoms that are a hallmark of the neurological disease. By monitoring resting tremors and other involuntary movements, the researchers were able to identify the characteristic "on" and "off" patterns of medication's effects. Their findings were published Wednesday in Science Translational Medicine.

The new system, called the Motor Fluctuations Monitor for Parkinson's disease (MM4PD), uses the Apple Watch's accelerometer and gyroscope data to detect the presence of resting tremor or dyskinesia. Resting tremors, which can affect the hands, legs, and other parts of the body, are a common symptom of Parkinson's. Dyskinesia, another type of involuntary movement, is a frequent side effect of medication used to treat the disease. The algorithms underlying the model were developed using data from a pilot study with 118 people in which researchers matched subject's smartwatch data to a scoring system called MDS-UPDRS Part III, the gold standard by which motor symptoms of Parkinson's are measured.

The authors say that the measurements helped spot symptoms missed in regular care and identified changes after subjects underwent surgery for deep brain stimulation. The paper also suggests the tool helped pinpoint people who slipped on medication adherence, as well as cases in which a person might benefit from a modified medication regimen.

"For most of her life, Joy Milne had a superpower that she was totally oblivious to," reports NPR. Long-time Slashdot reader doug141 explains what happened next: Milne's husband's natural odor changed when he was 31. He was diagnosed with Parkinson's at 45. When Joy walked into a Parkinson's support group, she smelled the same odor on everybody. A Parkinson's researcher tested her with blind samples from early stage patients, late-stage patients, and controls...
NPR tells the story of that test, which took place at the University of Edinburgh with a Parkinson's researcher named Tilo Kunath: [O]ut of all the samples, Joy made only one mistake. She identified a man in the control group, the group without Parkinson's, as having the disease. But many months later, Kunath says, that man actually approached him at an event and said, "Tilo, you're going to have to put me in the Parkinson's pile because I've just been diagnosed."

It was incontrovertible: Joy not only could smell Parkinson's but could smell it even in the absence of its typical medical presentation.

Kunath and fellow scientists published their work in ACS Central Science in March 2019, listing Joy as a co-author. Their research identified certain specific compounds that may contribute to the smell that Joy noticed on her husband and other Parkinson's patients. Joy and her super smelling abilities have opened up a whole new realm of research, Kunath says... Joy's superpower is so unusual that researchers all over the world have started working with her and have discovered that she can identify several kinds of illnesses — tuberculosis, Alzheimer's disease, cancer and diabetes.
Kunath says the ultimate goal is developing a new tool that can detect detect Parkinson's early. "Imagine a society where you could detect such a devastating condition before it's causing problems and then prevent the problems from even occurring."

An anonymous reader quotes a report from Gizmodo: Last October, researchers studied population data from more than a million Swedish residents and found that people who had their appendix removed were slightly less likely to develop Parkinson's. But other research has shown that there were no clear link between the two events. So Gregory Cooper and his team at Case Western Reserve University in Ohio decided to look with an even bigger microscope. They studied the electronic health records of more than 62 million Americans. Contrary to the October study, though, they spotted an increased risk of Parkinson's among those who had their appendix removed, roughly three times higher. And while Parkinson's starts becoming much more common in old age, a consistent added risk from appendix removal was even seen in those who developed it younger and across different ethnicities. "This is the largest study to date that's looked at this," Cooper told Gizmodo by phone this week. "And it's the most generalizable to the overall population, we think."

Cooper went on to say that this doesn't mean people shouldn't get an appendectomy if they need it: "Even with that threefold risk, it was still less than 1 percent of individuals who had an appendectomy and went on to develop Parkinson's. So in the grand scheme of things, it's a very low risk, and it shouldn't dissuade anyone from getting an appendectomy."

An anonymous reader quotes a report from Gizmodo: Scientists have found further evidence that the gut, or more specifically the appendix, might play a role in the development of Parkinson's disease. The international team of scientists reviewed two datasets, including a large registry from Sweden, and found that removal of the appendix was associated with a decreased risk of developing Parkinson's disease. They also found that the human appendix contains clumps of a protein called alpha-synuclein in a form associated with the disease. There's more work to be done, and the authors are not advocating that people preemptively remove their appendixes, but they hope that the research could provide a pathway towards treatment.

The study found that of the 1,144,745 Swedes who did not have appendectomies, 1,608 had Parkinson's, but of the 551,003 who had, only 644 had Parkinson's. This is amounts to a 16.9% decrease in the odds of acquiring the disease -- but in absolutes, that's the difference between an 0.14 percent chance of acquiring the disease for those who hadn't gotten their appendix removed versus an 0.11 percent chance for those who had. The effect was also stronger in those living in rural areas, according to the study published today in Science Translational Medicine. The researchers also found that for those who had appendectomies at least 30 years before developing Parkinson's, the procedure was associated with a 3.6-year delay in disease onset. The appendix samples contained alpha-synuclein proteins and shortened and mis-folded alpha-synucleins like the ones found in people with Parkinson's disease. Professor Viviane Labrie from the Cancer of Neurodegenerative Science at the Van Andel Research Institute in Michigan suggests that the alpha-synucleins "can travel up the nerve that connects the G.I. tract to the brain." She added: "If it were to enter the brain, it can seed and spread from there and have neurotoxic effects that could eventually lead to Parkinson's disease."

Blake Ellis and Melanie Hicken, writing for CNN: Two years ago, Brendan Tyne pleaded with the Food and Drug Administration to approve a drug that he was hopeful could finally bring his mother some peace. She could no longer move without assistance and had fallen victim to the debilitating and frightening psychosis that haunts many people with Parkinson's disease. "She thinks there are people in the house and animals are trying to get her," he told an FDA advisory committee. He believed that a new medication called Nuplazid, made by San Diego-based Acadia Pharmaceuticals, was the answer.

Nuplazid's review was being expedited because it had been designated a "breakthrough therapy" -- meaning that it demonstrated "substantial improvement" in patients with serious or life-threatening diseases compared to treatments already on the market. Congress created this designation in 2012 in an effort to speed up the FDA's approval process, which has long been criticized for being too slow. Around 200 drugs have been granted this designation since its creation. [...] The committee voted 12-2 and recommended that the FDA approve Nuplazid for the treatment of Parkinson's disease psychosis based on a six-week study of about 200 patients. It hit the market in June 2016. As caregivers and family members rushed to get their loved ones on it, sales climbed to roughly $125 million in 2017

[...] In November, an analysis released by a nonprofit health care organization, the Institute for Safe Medication Practices, warned that 244 deaths had been reported to the FDA between the drug's launch and March 2017. [...] Since the institute released its analysis, FDA data shows that the number of reported deaths has risen to more than 700. As of last June, Nuplazid was the only medication listed as "suspect" in at least 500 of the death reports.

An anonymous reader writes: My elderly monther-in-law misses her computer. Her mind is okay, but she cannot use a computer because of her Parkinson's disease.

I am not all that impressed with Amazon Echo. Seems you can ask the Echo for the time of day, or the weather outside, but it will not do anything useful -- like send an email. A voice controlled PC would be great, even if it only did a few simple tasks.
The original submission ends with a question: "Is there such a thing?" So leave your best thoughts and suggestions in the comments. Is there a useful voice-activated PC?

An anonymous reader writes: Called "Emma," it is a wrist wearable that can help people suffering with Parkinson's disease. The device is named after the Parkinson's sufferer that helped Haiyan Zhang, Innovation Director at Microsoft Research, create the device. What exactly does it do? Well, the incurable disease causes body tremors in those inflicted, and as a result, Emma has very shaky hands. This disease makes it impossible for her to draw straight lines or write legibly. With the wearable on her wrist, however, normal writing and drawing is possible. Remarkably, how it works isn't 100 percent known. "While the wait for a cure continues, Zhang has created what she hopes could be a 'revolutionary' aid for reducing tremors. The Emma Watch uses vibrating motors -- similar to those found in mobile phones -- to distract the brain into focusing on something other than trying to control the patient's limbs. Put simply, Zhang believes Lawton's brain is at war with itself -- half is trying to move her hand, the other half is trying to stop it. The two signals battle and amplify each other, causing the tremors. The device stops that feedback loop," says Microsoft. You will want to watch this video.

the_newsbeagle writes Pharmaceutical research for neuropsychiatric disorders hasn't produced many breakthroughs lately, which may explain why there's so much excitement around "electroceutical" research. That buzzy new field encompasses deep brain stimulation (DBS), in which an implanted stimulator sends little jolts through the neural tissue. DBS has become an accepted therapy for Parkinson's and other motor disorders, even though researchers haven't really understood how it works. Now, new research may have found the mechanism of action in Parkinson's patients: The stimulation reduces an exaggerated synchronization of neuron activity in the motor cortex.

hypnosec writes: Analogue, a theater/art group, has developed an interactive installation called "Transports," powered by the Raspberry Pi, that lets you experience symptoms of Parkinson's disease. In the illusion, a person's mind is tricked into believing that his/her hand is the hand shown in a point-of-view video, and the motorized glove worn by the user gives the feeling of tremors associated with Parkinson's. The glove recreates tremors, the ones experienced by patients, at 6 hertz – the upper limit of what is experienced by people with Parkinson's disease. Users are asked to follow instructions fed through headphones while using the glove, which creates an illusion of a virtual limb. They are supposed to mimic the movements of a man on the screen and manipulate real cutlery as he does.

carmendrahl writes "Exposure to certain pesticides, including rotenone and paraquat, has been associated with a higher incidence of Parkinson's disease in population studies. But how did scientists come to think of a link between Parkinson's disease and pesticides in the first place? The answer involves the 1980s drug underworld, where criminals were synthesizing modified versions of illegal drugs such as heroin to stay one step ahead of the law. One molecule in some designer heroin cocktails, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), breaks down in the human body into 1-methyl-4-phenylpyridinium (MPP+), a nerve cell killer. Heroin addicts exposed to this molecule got Parkinson's-like symptoms. As for the connection to pesticides, MPP+ is a weed killer that was used in the 70s. It also closely resembles the structure of the pesticide paraquat. The saga, therefore, put scientists on high alert to the possibility that pesticides might play a role in developing Parkinson's."

DavidHumus writes "A recent study indicates that consuming vegetables from the Solanaceae family, which includes tomatoes and peppers (as well as tobacco), decreases the risk of contracting Parkinson's disease. Earlier studies had shown that smoking tobacco seems to provide protection against the disease and the newer one seems to confirm that the key ingredient is nicotine, which is present in some vegetables like peppers."

another random user writes "Mathematician Max Little discovered that Parkinson's symptoms can be detected by computer algorithms that analyze voice recordings. Now he is looking for volunteers to contribute to a vast voice bank to help the database to learn even more. He is aiming to record up to 10,000 voices and has set up local numbers in 10 countries around the world."

dreampod writes "Canadian scientists have developed a microchip capable of monitoring the electrical and chemical communication channels between individual neurons. This is the first time scientists have been able to monitor the interaction between brain cells on such a precise and subtle level. In addition to providing the ability to see more easily the impact of drugs on various mental disorders during testing, this provides one of the first fundamental steps towards real mind-machine interface."

A former vice president of the University of Arizona, Sharon Kha, is fighting her Parkinson's disease in an unusual way — she's rapping. Even though there is no cure, some experts believe that the disease can be slowed with mental and physical exercises. For Kha that means writing, memorizing, and performing rap songs. She raps faster than she would normally speak, saying she has to "push myself verbally." From the article: "She's been rapping for the past three years. Each morning she walks a mile to her favorite midtown coffee shop ... often composing and reciting her rap songs as she walks. The songs, with names like 'Shake It!' and 'Tremor,' are sprinkled with insider information about Parkinson's, such as erratic sleep patterns, a fear of falling, and the frustration of putting on a sock."

futurity.org writes with news that Iowa State researchers have made a breakthrough that could eventually lead to a cure for Parkinson's. Identifying the protein that kills the dopamine-producing cells in the brain has allowed the researchers to disable it and could be the first step in the development of new treatments. "Now, Kanthasamy’s group is looking for additional compounds that also can serve to neutralize protein kinase-C. By identifying more compounds that perform the function of neutralizing kinase-C, researchers are more likely to locate one that works well and has few side effects. This discovery is expected to provide new treatment options to stop the progression of the disease or even cure it. 'Once we find the compound, we need to make sure it’s safe. If everything goes well, it could take about 10 years, and then we might be able to see something that will truly make a difference in the lives of people with this disorder,' says Kanthasamy."