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We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).


New Chemical Tools Lead To Targeted Cancer Drugs 21

Posted by Soulskill
from the sniper-scope-built-out-of-proteins dept.
New submitter caudex writes: Proteins are encoded in DNA, and while the degeneracy of the genetic code works to minimize errors, a single DNA basepair mutation can change the structure of the encoded protein. When a mutated protein causes uncontrolled cell growth, we call it cancer. Unfortunately, proteins typically contain hundreds of amino acids, and developing a drug that will target the version of a protein containing one amino acid mutation is difficult. For this reason, most anticancer agents indiscriminately attack both mutant and healthy proteins and tissues. Researchers at Caltech have come up with a potentially general method for selectively drugging only the mutant protein at fault for cancerous activity, even in the crowded and complex milieu of living cells. Their proof of concept study published in Nature Chemistry targets the E17K mutation, which can be the causative mutation of many types of cancer.

Comment: Re:We have already figured most of this out. (Score 2) 362

by wiggles (#49470565) Attached to: Can Civilization Reboot Without Fossil Fuels?

This is what killed Diesel as a car fuel in the US

That, and how dirty, sooty, and smelly the pre-EPA regulated diesel was. And the higher taxes levied by states in order to tax trucking more than cars due to their higher incidence of damage to the roads. And the tendency for non-treated diesel to gel in the winter time making it unreliable for cold environments until relatively recently.

The failure of diesel to catch on in the USA is hardly mysterious.


SpaceX Launch Postponed 77

Posted by samzenpus
from the second-time's-a-charm dept.
An anonymous reader writes with news about SpaceX's launch today and second attempt to land its Falcon 9 rocket on a platform floating offshore in the Atlantic ocean. "You can watch live as SpaceX launches its Falcon 9 rocket and attempts to recover the first stage portion via an automated, barge-based landing plan in the Atlantic ocean, with the first take-off attempted scheduled for 4:33 PM ET, provided conditions remain good and pre-flight checks go well. A big part of this mission, designated CRS-6 and designed primarily as a resupply flight for the International Space Station, is getting a second chance at recovering Falcon 9's first stage rocket. Once the second stage and the Dragon spacecraft detach from that first stage rocket, it'll undergo a controlled descent as it attempts to touch down with SpaceX's ocean-borne landing platform." Update: 04/13 21:43 GMT by S : The launch was scrubbed because of lightning in a nearby cloud. It's been rescheduled for tomorrow at 4:10PM ET.

Microsoft Engineer: Open Source Windows Is 'Definitely Possible' 303

Posted by Soulskill
from the cats-and-dogs-living-together dept.
An anonymous reader writes: Speaking at ChefCon, Microsoft Technical Fellow Mark Russinovich talked briefly about the prospect of some or all of Windows going open source. He said, "It's definitely possible. It's a new Microsoft." Russinovich acknowledged the reality that most developers and IT workers have embraced open source software to run some or all of their machines, and that means Microsoft needs to adapt. He also noted that Microsoft is beginning to adopt a strategy familiar to open source vendors: give away the software, and then sell support and related products. "It lifts them up and makes them available for our other offerings, where otherwise they might not be. If they're using Linux technologies that we can't play with, they can't be a customer of ours."

Parents Sue School After Pod Daughter Is Banned From Prom 33

Posted by samzenpus
from the pods-are-people-too dept.
With the prom season only a few months away kids and parents alike are starting to make plans for the big day. However, one girl's alien replacement might not get a chance to experience that special day if a school district has its way. Even though Darcy Swope's pod duplicate is virtually identical to her, the Santa Mira school district has decided she is not welcome to prom. School officials acknowledge the duplicate attended school and did Darcy's homework for an unknown period of time but say she isn't really a student and therefore doesn't belong at the dance. Darcy's parents disagree with the decision and have filed suit against the school, Her dad says, "We miss Darcy every day, but the thing that consumed her and is now pretending to be my daughter is almost the same and deserves to be treated the same." "She may not have that sparkle in her eye or the vocabulary as our flesh and blood daughter, but she has never missed curfew and has a thirst to learn. It would be a shame if Darcy II didn't get a chance to experience this important part of being human, even if she isn't one," adds her mother.

Comment: Re:There's only three plants. (Score 1) 417

by wiggles (#49330683) Attached to: How 'Virtual Water' Can Help Ease California's Drought

> Desalination from seawater costs about 8.5 kWH / m^3 {fixed}

At rates I pay (Illinois), that works out to be around $.35 per gallon. What's the problem? Charge farmers appropriately for what they use and everything will magically work, as they cut their production and raise their prices to a new equilibrium.

Comment: Re: This is pretty common. (Score 4, Funny) 193

If that's windows support, linux support is as follows:

Check /var/log messages for errors. Find cryptic bizarro language pointing to some subsystem you've never heard of. Craft messages as follows and post to Slashdot:

"Linux is terrible! I'm going back to Windows! I can't even get function XYZ to work! Every time I try, error message $ERR shows up in my /var/log/messages!"

Wait one hour before you get a response as follows:

"You moron, All you have to do to get that to go away is edit $CONFIG_FILE and restart $DAEMON! Windows sucks!"

Problem solved.

Comment: Re:Really, Slashdot? (Score 1) 230

by wiggles (#49189055) Attached to: Will you be using a mobile payment system?

I've had Google Wallet on my Nexus 4 since 2012. I used it for like a month, until the novelty wore off. It's just plain easier to open my wallet, grab a credit card, and swipe it through the reader than it is to get out my phone, unlock, find the wallet app, unlock fumble with the NFC scanner that doesn't always work, hope I have a decent server connection, and etc. I found that 7 out of 10 times I tried to use it, I wound up putting my phone away and digging out my wallet just to avoid pissing off all the other people in line behind me.

If you steal from one author it's plagiarism; if you steal from many it's research. -- Wilson Mizner