The thing everyone always ignores is that no matter what, eventually your brain dies. Whether in you or after you've been uploaded to a computer or another brain or what have you. And when that happens *THAT* you is dead. *YOU* still experience the pain of death. YOU still cease to exist. There is something out there with your memories and thoughts, but they are not you any more than a photo album or journal is you.
The me that got up this morning is not exactly the same me that went to bed last night either, and yet I am still me.
At the point where something is simulated with 100% accuracy it is no different than the original.