There are numerous different scenarios. Long haul trucking (for example) may end up being totally autonomous, just having a human driver picked up when close to leaving the freeway system.
Local delivery (Fed Ex, UPS etc) will still have an operator (or perhaps two or more) that can jump out with the package while the delivery truck drives around the block (or drops the second operator at a second location.) While going between locations the operators sort packages. When empty the operators may get dropped off for coffee while the truck heads back to the depot and a second full truck heads out to pick them up.
Its all about effectively managing resources and reducing costs. People will continue to have a place just a different one.