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+ - ALS Treatment Hope: Researchers Discover How to Stop Brain Rejecting Drugs->

Submitted by concertina226
concertina226 (2447056) writes "Scientists at Thomas Jefferson University have discovered that blocking certain types of proteins in the brain may help drugs that have so far failed to treat Amyotrophic lateral sclerosis (ALS) to be able to work.

Currently there is only one drug in the world, called Riluzole, that is approved for treating ALS. Riluzole works by suppressing the activity of glutamate – a chemical messenger in the central nervous system.

Unfortunately, Riluzole has been shown to lose its effectiveness in patients as the disease progresses, and it only prolongs the lives of ALS patients for between three to six months.

The researchers decided to analyse the brains of mice infected with ALS, instead of analysing healthy animals. They identified two specific pumps in the brain that interact with Riluzole, namely P-glycoprotein (P-gp) and breast-cancer resistant protein.

When they blocked these two types of proteins by treating the mice with an experimental compound called Elacridar together with Riluzole, the scientists found that the treatments extended the life span of the mice and alleviated some of the disease's symptoms, such as improving and preserving muscle strength."

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Comment: Re:I see why the boson is a "God Particle" (Score -1) 67

by rmdingler (#48414649) Attached to: Elusive Dark Matter May Be Detected With GPS Satellites
l looked up your posting history before replying in case you're normal habit of posting insightfully had been interrupted briefly by a temporary aphasia, and I am disappointed to say your posting history has been found to be a tad lackluster.

If you were attempting to garner positive moderation through razor-thinly veiled, pretentious, intellectual criticism, well... hold on to your day job a bit longer.

Comment: Re:"eye sore" (Score 2, Insightful) 490

by rmdingler (#48414609) Attached to: Rooftop Solar Could Reach Price Parity In the US By 2016
Demor, you say.

Please remember. In the rush to vilify various and sundry sources of energy vis-a-vis environmental impact, that all energy comes at an environmental cost. We will not do without the electricity in our homes and fuel for our human-toters and goodie-transport vehicles.

One day, when the other grid-friendly options are all exploited, our offspring will enjoy ubiquitous clean and relatively safe nuclear power.

Comment: Re: "individuals under investigation" (Score 2) 200

by rmdingler (#48385035) Attached to: Department of Justice Harvests Cell Phone Data Using Planes
"everyone" will be translated into something grotesquely governmental like subjects of interest, which will include you if your cousin's niece's hairdresser's brother-in-law took a Middle Eastern Studies freshman course.

Boeing cooperating with the government is like my son cooperating with me and taking out the garbage. I'm his biggest source of income.

Comment: Re:Meet the new boss, same as the old boss. (Score 1) 127

by rmdingler (#48377419) Attached to: Senate May Vote On NSA Reform As Soon As Next Week
Texas Lt Governor Dan Patrick won statewide office prominently supporting a minimum raise increase, and while Governor-elect Greg Abbott has flopped on the issue since he was the Atty. General, I remain convinced that most politicians would say whatever they believed you needed to hear to get your vote.

Get the votes now, ask for forgiveness later.

Comment: It's too bad, really (Score 2) 223

by rmdingler (#48377319) Attached to: Overbilled Customer Sues Time Warner Cable For False Advertising
Given the general sentiment toward cable providers and their malevolent indifference to improve service, I can reasonably see loading a jury with folks predisposed to angst with their own service.

It's too bad this plaintiff will have a difficult time outlasting the cable giant's efforts at playing lawsuit.

Comment: Re:Meet the new boss, same as the old boss. (Score 1) 127

by rmdingler (#48377249) Attached to: Senate May Vote On NSA Reform As Soon As Next Week

That's because both parties want that sweeping power for when *they're* in charge.

Almost certainly. Which begs the question, "How much difference is there, really, between the choices available on election day?"

In retrospect, that security theatre works its magic at airports should in no way surprise us since we've been indulging in political theatre for some time now.

Comment: Meet the new boss, same as the old boss. (Score 4, Insightful) 127

by rmdingler (#48377133) Attached to: Senate May Vote On NSA Reform As Soon As Next Week
I listened to campaign ads from parts of the country considered liberal, and from regions considered conservative this election season. Assuming the candidates were attempting to address issues important to voters, the topics ran the gamut from job creation to how malevolent the opposition candidate was.

Not once did a political ad obviously endorse curtailing the government's sweeping surveillance powers.

Candidates from elections are prone to endorse whatever view the polls say their constituents are interested in. I'd say this is a poor harbinger of curtailing the powers of the surveillance state.

Promising costs nothing, it's the delivering that kills you.

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