That depends on what you mean by "tangible benefits." One argument I've heard for practical, what's-in-it-for-me-today benefits is that the technology produces spin-offs such as techniques to mass-produce rare-earth magnets, the world-wide web, etc. But that's honestly a weak argument because there's a lot of research going on that has similar chances to produce spin-off tech.
For particle physics, the feeling is that we are on the verge of some kind of revolution! Admittedly it's been that way for a few decades now, but the current working theory (the standard model) has a number of deep problems (thanks wikipedia!). Most new theories, and there are a whole lot of them, predict new phenomena just at the edge of our experimental reach. Part of that is because well-meaning theorists prefer to propose theories that are either presently or soon-to-be testable. But part of it is because the experimental frontier has advanced to energies at roughly the electroweak unification point and lots of theories have interesting behavior to predict at this point, broadly speaking.
So it's not just a more-is-better kind of effort that won't stop until we build solar-system-sized accelerators. There really is a sense that a major shift, possibly even a philosophically-challenging development, is nearly within our grasp, within our lifetimes. This is not a "practical" argument for basic science, but only history can tell us what has had short and long-term practical benefits. History does tell us that this sort of pursuit has in the past been enormously beneficial. Maybe we are in a whole new era where new physics will be completely impractical, but that would honestly be surprising if true.