Without something to anchor your 500-1000 number, who will know how outraged they need to be?
And without knowing what those investigators were doing neither number is particularly useful. That's 1000 investigators and their entire lab staff most of them being scientists doing useful research not administrators etc. Unfortunately this doesn't just affect the current generation of scientists, it affects the next generation too. Not all of these labs will close, but there will certainly be a lot less capacity to take students and post docs. How this will impact research is pretty hard to predict, unfortunately it looks a bit more like the blunderbuss approach than the precision cull of the herd with a rifle and scope.