Since bugs like those crop up anyway[...]
Well, that's the thing... Do they crop up anyway or are these bugs already the intentional backdoors?
What remains is that the genetic pool can't be refreshed easily during the long journey, when multiplying the conventional way. So enough sperm and ovules would be required to have the crew survive long enough. (A kind of rotation might be OK, current crew might donate something to be used in later generations.)
Thinking about it, we might plan a project already and assemble a premium crew for it. Top politicians, top managers, top hairdressers and phone desinfectors.
Probably less tempting for those trying to implement censorship...