This is what doomed the Shuttle. It was designed for a totally different mission profile than it was used for. It had unused polar launch capability (from Vanderburg AFB) and large cross-range ability that was not necessary at all to reach the ISS. This caused the shuttle to be heavier, with less range and more expensive than it could have been for the missions it was used for.
I have no doubt that SLS will become the same disaster, as it is going to be designed to do "every mission" and end up doing them all for far more money than it could have.