Keep in mind that Mac OS X supports case-sensitive HFS+ filesystems, and has done so from Mac OS X 10.3 on (2003). All you have to do is create a partition with that particular flavour of HFS+.
Stepping back from HFS+ they've even supported case-sensitive file systems long before that since you could use UFS on OS X. Even OS 9 supported it but I don't remember if you could boot that from it.
However, Adobe refuses to support case-sensitive filesystems. The Photoshop installer refuses to install on a case-sensitive filesystem, and Lightroom geolocation support is broken on case-sensitive filesystems, and always has been. Of course this limitation is not documented in their sales documentation, and the official fix is to reformat the partition...
Yep. The Adobe suite won't even open files over NFS.